1,7-DIHYDRO-2-METHYL-6-PURINONE

Base Information

• Chemical Name: 1,7-DIHYDRO-2-METHYL-6-PURINONE
• CAS No.: 5167-18-0
• Molecular Formula: C₆H₆N₄O
• Molecular Weight: 150.14
• Hs Code.: 2933990090
• Mol file: 5167-18-0.mol

Synonyms:6H-Purin-6-one,1,7-dihydro-2-methyl- (9CI); Hypoxanthine, 2-methyl- (7CI,8CI);1,7-Dihydro-2-methyl-6-purinone; 2-Methyl-6-hydroxypurine; 2-Methylhypoxanthine

Chemical Property of 1,7-DIHYDRO-2-METHYL-6-PURINONE

Chemical Property:

• Boiling Point: 484.3°Cat760mmHg
• Flash Point: 246.7°C
• PSA: 74.69000
• Density: 1.72g/cm³
• LogP: 0.36690
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-3H-purin-6(7H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,7-DIHYDRO-2-METHYL-6-PURINONE

There total 13 articles about 1,7-DIHYDRO-2-METHYL-6-PURINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-(methyl(ethoxy)methylene)-aminoimidazole-4-carboxamide (117987-01-6) → 2-methyl-6-hydroxypurine (5167-18-0)

Guidance literature:

at 200 ℃; for 0.5h;

DOI:10.1021/jm300351w

Reference yield: 49.0%

5-(methyl(ethoxy)methylene)-aminoimidazole-4-carboxamide (117987-01-6) → 2-Methyl-hypoxanthin (5167-18-0)

Guidance literature:

at 240 ℃; for 0.333333h;

Reference yield:

5-amino-1H-imidazole-4-carboxamide monohydrochloride (72-40-2) + ethyl acetate (141-78-6) → 2-Methyl-hypoxanthin (5167-18-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 24h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.200800627

upstream raw materials:

quinoline

5-Acetamido-4-amino-2-methylpyrimidine-6-(1H)-one

formamide

5,6-diamino-2-methylpyrimidin-4(3H)-one sulfate

Downstream raw materials:

6-chloro-2-methyl-9H-purine

2-methyl-1,9-dihydro-purine-6-thione

2-methyl-6-methylsulfanyl-7(9)H-purine

6-Chloro-9-(2-fluoro-benzyl)-2-methyl-9H-purine

Refernces

• 1、 -. "DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY". Page/Page column 32. . Retrieved 2009/07/25.
• 2、 Biagi,Giorgi,Livi,Scartoni,Tonetti,Lucacchini. "Xanthine oxidase (XO): Relative configuration of complexes formed by the enzyme, 2- or 8-N-alkylhypoxanthines and 2-N-alkyl-8-azahypoxanthines. XII". . p. 357 - 374. Retrieved 2007/10/02.