Glycylglycine hydrochloride

Base Information

• Chemical Name: Glycylglycine hydrochloride
• CAS No.: 13059-60-4
• Molecular Formula: C4H9ClN2O3
• Molecular Weight: 168.58
• Hs Code.: 2924199090
• European Community (EC) Number: 235-951-2,245-913-7
• DSSTox Substance ID: DTXSID1065342
• Metabolomics Workbench ID: 71575
• Mol file: 13059-60-4.mol

Synonyms:Diglycine;Glycyl Glycine;Glycyl-Glycine;Glycylglycine;Glycylglycine Hydrochloride;Glycylglycine Monohydrochloride;Hydrochloride, Glycylglycine;Monohydrochloride, Glycylglycine;N Glycylglycine;N-Glycylglycine

Chemical Property of Glycylglycine hydrochloride

Chemical Property:

• Vapor Pressure: 1.78E-09mmHg at 25°C
• Melting Point: 125-129°C(lit.)
• Boiling Point: 453.2 °C at 760 mmHg
• Flash Point: 227.9 °C
• PSA: 92.42000
• LogP: 0.03910
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 168.0301698
• Heavy Atom Count: 10
• Complexity: 123

Purity/Quality:

98%,99%, ^*data from raw suppliers

GlycylglycineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)NCC(=O)O)N.Cl
• Uses: Glycylglycine is a derivative of Glycine (G615990), a non-essential amino acid that enhances N-methyl-D-aspartate (NMDA) receptor mediated synaptic potentials in the neocortex of rats. Glycine is also being used as adjuvant therapy for the treatment of schizophrenia.

Technology Process of Glycylglycine hydrochloride

There total 2 articles about Glycylglycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

C10H10N3O7P(2-)*2Na(1+) → 4-nitropheylphosphonic acid (2175-86-2) + glycylglycine hydrochloride (13059-60-4)

Guidance literature:

With citric acid;

DOI:10.1016/S0040-4020(01)97957-8

Reference yield:

C19H21F2N2O5P (77930-08-6) → (difluoromethyl)phosphonic acid (74963-39-6) + glycylglycine hydrochloride (13059-60-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Multistep reaction; 1.) methanol;

DOI:10.1016/S0040-4020(01)97957-8

Reference yield: 90.0%

glycylglycine hydrochloride (13059-60-4) + Z-Cys(BzlOMe)-ONSu (77374-43-7) → Z-Cys(BzlOMe)-Gly2-OH (77374-52-8)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 24h; Ambient temperature;

DOI:10.1039/P19810000310

upstream raw materials:

C₁₉H₂₁F₂N₂O₅P

Downstream raw materials:

hippuroyl-Gly-Gly

N-benzoyl-alanyl-glycyl-glycine

N-benzoyl-tetraglycyl-glycine

chloroacetyldiglycine

Refernces