3,5-DICHLORO-2-HYDROXYBENZOPHENONE

Base Information

• Chemical Name: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE
• CAS No.: 7396-92-1
• Molecular Formula: C13H8Cl2O2
• Molecular Weight: 267.111
• Hs Code.: 2914700090
• Mol file: 7396-92-1.mol

Synonyms:Benzophenone,3,5-dichloro-2-hydroxy- (6CI,7CI,8CI);(3,5-Dichloro-2-hydroxyphenyl)(phenyl)methanone;3,5-Dichloro-2-hydroxybenzophenone;3,5-Dichloro-2-hydroxyphenyl phenyl ketone;

Chemical Property of 3,5-DICHLORO-2-HYDROXYBENZOPHENONE

Chemical Property:

• Vapor Pressure: 3.34E-06mmHg at 25°C
• Melting Point: 115 °C
• Refractive Index: 1.631
• Boiling Point: 376.5 °C at 760 mmHg
• Flash Point: 181.5 °C
• PSA: 37.30000
• Density: 1.406 g/cm³
• LogP: 3.93000

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dichloro-2-hydroxybenzophenone Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-53-36/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DICHLORO-2-HYDROXYBENZOPHENONE

There total 6 articles about 3,5-DICHLORO-2-HYDROXYBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,5-dichloro-2-hydroxyphenyl phenyl ketone oxime → (3,5-dichloro-2-hydroxyphenyl)(phenyl)methanone (7396-92-1)

Guidance literature:

With selenium(IV) oxide; In toluene; Heating;

Reference yield: 32.0%

phenylboronic acid (98-80-6) + 3,5-dichlorosalicyclaldehyde (90-60-8) → (3,5-dichloro-2-hydroxyphenyl)(phenyl)methanone (7396-92-1)

Guidance literature:

With pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(I) bromide; In tert-Amyl alcohol; at 130 ℃; for 48h; chemoselective reaction; Sealed tube;

DOI:10.1002/chem.202004810

Reference yield:

benzoyl chloride (98-88-4) + 2,4-dichlorophenol (120-83-2,40477-79-0) → (3,5-dichloro-2-hydroxyphenyl)(phenyl)methanone (7396-92-1)

Guidance literature:

With aluminum (III) chloride; In neat (no solvent); at 110 ℃; for 0.166667h; chemoselective reaction;

DOI:10.4314/bcse.v29i2.14

upstream raw materials:

benzoyl chloride

2,4-dichlorophenol

benzene

phenylboronic acid

Downstream raw materials:

5,7-dichloro-3-phenylbenzofuran

Refernces

• 1、 Gaikwad, Sunil V.,Nawghare, Beena R.,Lokhande, Pradeep D.. "Chemoselective C-benzoylation of phenols by using ALCl3under solvent-free conditions". . p. 319 - 325. Retrieved 2015/07/27.