4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER
• CAS No.: 281235-04-9
• Molecular Formula: C13H17 N O2
• Molecular Weight: 219.283
• Hs Code.: 2933399090
• Mol file: 281235-04-9.mol

Synonyms:4-Piperidin-4-ylbenzoicacid methyl ester; Methyl 4-(piperidin-4-yl)benzoate

Chemical Property of 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 8.65E-05mmHg at 25°C
• Boiling Point: 340.3°C at 760 mmHg
• Flash Point: 159.6°C
• PSA: 38.33000
• Density: 1.071g/cm³
• LogP: 2.26900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-Piperidin-4-yl-benzoicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER

There total 8 articles about 4-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-(piperidin-4-yl)-benzoic acid (196204-01-0) → methyl 4-(piperidine-4-yl)benzoate (281235-04-9)

Guidance literature:

With thionyl chloride; at 20 ℃;

Reference yield: 95.0%

methyl 4-(piperidine-4-yl)benzoate hydrochloride (936130-82-4) → methyl 4-(piperidine-4-yl)benzoate (281235-04-9)

Guidance literature:

With ammonia; In methanol;

Reference yield: 82.4%

4-Pyridin-4-yl-benzoic acid methyl ester (106047-17-0) → methyl 4-(piperidine-4-yl)benzoate (281235-04-9)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; for 18h; under 2250.23 Torr;

upstream raw materials:

4-Pyridin-4-yl-benzoic acid methyl ester

4-(piperidin-4-yl)-benzoic acid

methyl 4-(piperidine-4-yl)benzoate hydrochloride

methanol

Downstream raw materials:

methyl 4-(1-prop-2-enylpiperidin-4-yl)benzoate

methyl 4-(1-cyano-4-piperidyl)benzoate

methyl 4-[1-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]-4-piperidyl]benzoate

C₁₉H₂₇N₃O₅

Refernces

• 1、 -. "BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS". Page/Page column 28-29. . Retrieved 2020/10/28.
• 2、 -. "Carboxylic acids and the esters thereof, pharmaceutical compositions thereto and processes for the preparation thereof". Page 29. . Retrieved 2008/06/13.