Ethyl 5-amino-2-pyrazinecarboxylate

Base Information

• Chemical Name: Ethyl 5-amino-2-pyrazinecarboxylate
• CAS No.: 54013-06-8
• Molecular Formula: C7H9N3O2
• Molecular Weight: 167.167
• Hs Code.: 2933990090
• Mol file: 54013-06-8.mol

Synonyms:Pyrazinecarboxylicacid, 5-amino-, ethyl ester (7CI,9CI);Ethyl 5-amino-2-pyrazinecarboxylate;

Chemical Property of Ethyl 5-amino-2-pyrazinecarboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 174-175 °C
• Refractive Index: 1.563
• Boiling Point: 365.617 °C at 760 mmHg
• PKA: 0.78±0.10(Predicted)
• Flash Point: 174.919 °C
• PSA: 78.10000
• Density: 1.261 g/cm³
• LogP: 0.81670
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl5-Aminopyrazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-amino-2-pyrazinecarboxylate

There total 1 articles about Ethyl 5-amino-2-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl 5-aminopyrazine-2-carboxylate (54013-06-8)

Guidance literature:

5-Amino-pyrazin-2-carbonsaeure (X) u. absol. EtOH/SOCl2/Δ; S.156;

Reference yield: 20.0%

3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid (1380646-44-5) + 5-amino-pyrazine-2-carboxylic acid methyl ester (13924-94-2) + ethyl 5-aminopyrazine-2-carboxylate (54013-06-8) → 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)propionylamino]-pyrazine-2-carboxylic acid methyl ester (1380646-64-9) + 5-[3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazine-2-carboxylic acid ethyl ester (1380645-91-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

(6-bromo-3-methyl-2-phenylquinolin-4-yl)(1H-imidazol-1-yl)methanone + ethyl 5-aminopyrazine-2-carboxylate (54013-06-8) → 5-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}pyrazine-2-carboxylic acid

Guidance literature:

(6-bromo-3-methyl-2-phenylquinolin-4-yl)(1H-imidazol-1-yl)methanone; ethyl 5-aminopyrazine-2-carboxylate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃;

With sodium hydroxide; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Downstream raw materials:

5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)propionylamino]-pyrazine-2-carboxylic acid methyl ester

5-[3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazine-2-carboxylic acid ethyl ester

ethyl 2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenyl-imidazo[1,2-a]pyrazine-6-carboxylate

ethyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-a]pyrazine-6-carboxylate

Refernces

• 1、 Foks. "Pyrazine-2-carboxylic acid N-oxides. IV. Reaction of pyrazine-2-carboxamide 4-N-oxide with phosphorus oxycholoride". . p. 153 - 161. Retrieved 2007/10/04.