2-AMINO-6-BENZOTHIAZOLOL HCL

Base Information

• Chemical Name: 2-AMINO-6-BENZOTHIAZOLOL HCL
• CAS No.: 26278-78-4
• Molecular Formula: C7H6N2OS^.HCl
• Molecular Weight: 202.664
• Hs Code.: 2934200090
• Mol file: 26278-78-4.mol

Synonyms:6-Benzothiazolol,2-amino-, monohydrochloride (8CI,9CI);2-Amino-6-benzothiazolol hydrochloride;

Chemical Property of 2-AMINO-6-BENZOTHIAZOLOL HCL

Chemical Property:

• Vapor Pressure: 2.79E-07mmHg at 25°C
• Melting Point: 263-265 °C
• Boiling Point: 409.2°Cat760mmHg
• Flash Point: 201.3°C
• PSA: 87.38000
• LogP: 2.96730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Aminobenzo[d]thiazol-6-olhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-BENZOTHIAZOLOL HCL

There total 1 articles about 2-AMINO-6-BENZOTHIAZOLOL HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

thiourea (17356-08-0) + p-benzoquinone (106-51-4) → 2-amino-6-hydroxybenzothiazole hydrochloride salt (26278-78-4)

Guidance literature:

thiourea; With hydrogenchloride; In ethanol; water; for 0.5h;

p-benzoquinone; In ethanol; water; at 25 ℃; for 24h;

DOI:10.3906/kim-1801-76

Reference yield: 78.0%

2-amino-6-hydroxybenzothiazole hydrochloride salt (26278-78-4) → 2-amino-6-hydroxybenzothiazole (26278-79-5)

Guidance literature:

With sodium acetate; In water;

Reference yield:

2-amino-6-hydroxybenzothiazole hydrochloride salt (26278-78-4) → 2-cyano-6-hydroxybenzothiazole (939-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate / water

2.1: tetrafluoroboric acid; sodium nitrite / water / 1 h / 0 °C

3.1: dibenzo-18-crown-6; copper(II) tetrafluroborate hexahydrate; copper(l) cyanide / acetonitrile / 0.25 h

3.2: 0.5 h / 25 °C

3.3: 1 h / 25 °C / Sealed tube; Inert atmosphere

With tetrafluoroboric acid; dibenzo-18-crown-6; copper(II) tetrafluroborate hexahydrate; sodium acetate; copper(l) cyanide; sodium nitrite; In water; acetonitrile; 3.1: |Sandmeyer Reaction / 3.2: |Sandmeyer Reaction / 3.3: |Sandmeyer Reaction;

DOI:10.3906/kim-1801-76

upstream raw materials:

thiourea

p-benzoquinone

Downstream raw materials:

p-nitrobenzyl-6-hydroxybenzothiazole-2-carbamate

1-(6-hydroxybenzo[d]thiazol-2-yl)-3-phenylurea

2-amino-6-hydroxybenzothiazole

2-cyano-6-hydroxybenzothiazole

Refernces

• 1、 -. "SOLID FORMS COMPRISING N-(5-TERT-BUTYL-ISOXAZOL-3-YL)-N'-{4-[7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B][1,3]BENZOTHIAZOL-2-YL]PHENYL}UREA, COMPOSITIONS THEREOF, AND USES THEREWITH". Page/Page column 84. . Retrieved 2009/04/25.