3-(Furan-2-yl)aniline

Base Information

• Chemical Name: 3-(Furan-2-yl)aniline
• CAS No.: 102269-42-1
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID10400097
• Nikkaji Number: J2.663.833J
• Wikidata: Q82202927
• Mol file: 102269-42-1.mol

Synonyms:3-(furan-2-yl)aniline;102269-42-1;3-(2-furyl)aniline;[3-(2-Furyl)phenyl]amine HCl;Benzenamine,3-(2-furanyl)-;3-(Fur-2-yl)aniline;3-(uran-2-yl)aniline;3-CHLOROSALICYLICACID;SCHEMBL2462178;DTXSID10400097;3-(2-furyl)aniline, AldrichCPR;CHEBI:194802;MFCD04039071;AKOS000314403;MS-22372;BB 0220544;CS-0365742;FT-0642479

Chemical Property of 3-(Furan-2-yl)aniline

Chemical Property:

• Vapor Pressure: 0.000533mmHg at 25°C
• Melting Point: 53 °C
• Refractive Index: 1.593
• Boiling Point: 312.3 °C at 760 mmHg
• Flash Point: 142.7 °C
• PSA: 39.16000
• Density: 1.138 g/cm³
• LogP: 3.11000
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

3-(Fur-2-yl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)N)C2=CC=CO2

Technology Process of 3-(Furan-2-yl)aniline

There total 4 articles about 3-(Furan-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(3-nitrophenyl)-furan (28988-01-4) → 3-(furan-2-yl)aniline (102269-42-1)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; for 1h; Heating;

DOI:10.1007/BF00758570

Reference yield: 50.0%

3-Aminophenylboronic acid (30418-59-8,280563-63-5) + 2-(n-butyltellanyl)furan (408492-37-5) → 3-(furan-2-yl)aniline (102269-42-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide; In methanol; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1071/CH08255

Reference yield:

fur-2-ylboronic acid (13331-23-2) + m-Bromoaniline (591-19-5) → 3-(furan-2-yl)aniline (102269-42-1)

Guidance literature:

fur-2-ylboronic acid; m-Bromoaniline; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

With sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2h;

upstream raw materials:

2-(3-nitrophenyl)-furan

3-Aminophenylboronic acid

2-(n-butyltellanyl)furan

fur-2-ylboronic acid

Downstream raw materials:

2-[(3-Furan-2-yl-phenylamino)-methylene]-malonic acid diethyl ester

Diethyl 7-(furyl-2)-1,4-dihydro-4-oxoquinoline-3-carboxylate

1,4-dichloro-phthalazine-6-carboxylic acid (3-furan-2-yl-phenyl)-amid

C₂₅H₂₀F₆N₂O₃

Refernces

• 1、 -. "3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS". Page/Page column 34-35. . Retrieved 2009/08/16.
• 2、 Glushkov, R. G.,Adamskaya, E. V.,Oleinik, A. F.,Silin, V. A.,Padeiskaya, E. N.,Solov'eva N. P.. "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6- AND 7--1-ETHYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS". . p. 200 - 203. Retrieved 2007/10/02.