2-Methoxyacetohydrazide

Base Information

• Chemical Name: 2-Methoxyacetohydrazide
• CAS No.: 20605-41-8
• Molecular Formula: C3H8N2O2
• Molecular Weight: 104.109
• Hs Code.: 2928000090
• European Community (EC) Number: 670-615-2
• DSSTox Substance ID: DTXSID50374824
• Nikkaji Number: J2.748.435B
• Wikidata: Q82163389
• Mol file: 20605-41-8.mol

Synonyms:2-methoxyacetohydrazide;20605-41-8;Methoxyacetic acid hydrazide;Acetic acid, methoxy-, hydrazide;2-methoxyethanehydrazide;MFCD02197887;methoxyacetohydrazide;Oprea1_377226;SCHEMBL314795;2-methoxyacetic acid hydrazide;Acetic acid,2-methoxy-,hydrazide;AMY3068;DTXSID50374824;XEPXDMNZXBUSOI-UHFFFAOYSA-N;Acetic acid, 2-methoxy-, hydrazide;BBL013411;STK346606;AKOS000138657;methoxymethyl-carboxylic acid hydrazide;CS-W005634;SB86281;AS-11191;SY109583;BB 0256682;FT-0628305;EN300-108832;F14662;A814734

Chemical Property of 2-Methoxyacetohydrazide

Chemical Property:

• Vapor Pressure: 0.00643mmHg at 25°C
• Melting Point: 58-59 °C
• Refractive Index: 1.441
• Boiling Point: 271.5 °C at 760 mmHg
• PKA: 12.29±0.18(Predicted)
• Flash Point: 118 °C
• PSA: 64.35000
• Density: 1.107 g/cm³
• LogP: -0.28610
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.058577502
• Heavy Atom Count: 7
• Complexity: 64

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxyacetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)NN
• Uses: 2-Methoxyacetohydrazide is used in preparation of Benzylaminopyrazolopyrimidinone derivatives and analogs for use as DNA polymerase IIIC inhibitors.

Technology Process of 2-Methoxyacetohydrazide

There total 5 articles about 2-Methoxyacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl methoxyacetate (6290-49-9) → methoxyacetic acid hydrazide (20605-41-8)

Guidance literature:

With hydrazine; In methanol; Reflux;

DOI:10.1016/j.bmcl.2009.11.097

Reference yield:

ethyl 2-methoxyacetate (3938-96-3) → methoxyacetic acid hydrazide (20605-41-8)

Guidance literature:

With hydrazine; In ethanol; for 3h; Heating;

DOI:10.1016/0223-5234(90)90168-3

Reference yield:

sodium methylate (124-41-4) + methyl chloroacetate (96-34-4) → methoxyacetic acid hydrazide (20605-41-8)

Guidance literature:

sodium methylate; methyl chloroacetate; In methanol; at 20 ℃; for 3h;

With hydrazine hydrate; In methanol; at 80 ℃; for 8h;

DOI:10.1039/b910255h

upstream raw materials:

2-methoxyacetic acid

ethyl 2-methoxyacetate

methyl methoxyacetate

sodium methylate

Downstream raw materials:

Methoxy-acetic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

8-chloro-3-methoxymethyl-6-(4-nitrophenyl)-11H-1,2,4-triazolo[4,5-c][2,3]benzodiazepine

2-methoxymethyl-1,3,4-thiadiazole-5-thiol

2-methoxyacetyl-N-phenylhydrazinecarbothioamide

Refernces

• 1、 Brown, Alan,Brown, T. Bruce,Calabrese, Andrew,Ellis, Dave,Puhalo, Nicholas,Ralph, Michael,Watson, Lesa. "Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent". scheme or table. p. 516 - 520. Retrieved 2010/04/05.
• 2、 -. "Substituted triazole derivatives as oxytocin antagonists". Page/Page column 22. . Retrieved 2008/06/13.