Imidazo[1,2-a]pyridine-6-carboxylic acid

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-6-carboxylic acid
• CAS No.: 139022-25-6
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 2933990090
• European Community (EC) Number: 640-508-5
• DSSTox Substance ID: DTXSID00427738
• Wikidata: Q72534616
• Mol file: 139022-25-6.mol

Synonyms:Imidazo[1,2-a]pyridine-6-carboxylic acid;139022-25-6;MFCD07021498;Imidazo[1,2-a]pyridine-6-carboxylicacid;SCHEMBL173528;1H-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID;DTXSID00427738;ONOJJCTXSDBVSP-UHFFFAOYSA-N;BCP17435;AKOS005071089;CS-W005545;PB10400;AC-26547;SY005596;Imidazo[1,2-a]pyridine-6-carboxylic?acid;imidazol[1,2-a]pyridine-6-carboxylic acid;AM20050806;FT-0647443;EN300-66821;A21888;7X-0867;Imidazo[1,2-a]pyridine-6-carboxylic acid, AldrichCPR;Z825455558

Chemical Property of Imidazo[1,2-a]pyridine-6-carboxylic acid

Chemical Property:

• Melting Point: 250 °C
• Refractive Index: 1.676
• PKA: 0.67±0.41(Predicted)
• PSA: 54.60000
• Density: 1.418 g/cm³
• LogP: 1.03250
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 162.042927438
• Heavy Atom Count: 12
• Complexity: 196

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridine-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 22-26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C=C1C(=O)O

Technology Process of Imidazo[1,2-a]pyridine-6-carboxylic acid

There total 11 articles about Imidazo[1,2-a]pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ imidazo[1,2-a]pyridine-6-carboxylic acid (139022-25-6)

Guidance literature:

Reference yield: 78.0%

imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester (158001-04-8) → imidazo[1,2-a]pyridine-6-carboxylic acid (139022-25-6)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 25 ℃; for 2h;

Reference yield: 77.0%

imidazo[1,2-a]pyridin-6-carboxylic acid hydrochloride (1314777-15-5) → imidazo[1,2-a]pyridine-6-carboxylic acid (139022-25-6)

Guidance literature:

With sodium hydroxide; In water;

upstream raw materials:

methyl 6-imidazo<1,2-a>pyridinecarboxylate

methyl 6-aminonicotinoate

6-aminonicotinic acid

1-bromo-2,2-dimethoxyethane

Downstream raw materials:

methyl 6-imidazo<1,2-a>pyridinecarboxylate

N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide

N-({4-[3-(trifluoromethyl)benzenesulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide

N-[(4-{[6-(morpholin-4-yl)pyridin-3-yl]sulfonyl}phenyl)-methyl]imidazo[1,2-a]pyridine-6-carboxamide

Refernces

• 1、 -. "IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF". Page/Page column 24-26. . Retrieved 2020/05/07.
• 2、 -. "SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS". Paragraph 00528-00529. . Retrieved 2015/05/19.