N-CBZ-DL-HISTIDINE

Base Information

• Chemical Name: N-CBZ-DL-HISTIDINE
• CAS No.: 19728-57-5
• Molecular Formula: C14H15N3O4
• Molecular Weight: 289.291
• Hs Code.: 29339900
• Mol file: 19728-57-5.mol

Synonyms:DL-Histidine,N-[(phenylmethoxy)carbonyl]-;Histidine, N-carboxy-, N-benzyl ester, DL- (8CI);NSC 169138;Na-Benzyloxycarbonyl-DL-histidine;Carbobenzoxy-dl-histidine;

Chemical Property of N-CBZ-DL-HISTIDINE

Chemical Property:

• Boiling Point: 616.7 °C at 760 mmHg
• Flash Point: 326.8 °C
• PSA: 104.31000
• Density: 1.368 g/cm³
• LogP: 1.72270
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-[(Benzyloxy)carbonyl]-L-histidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CBZ-DL-HISTIDINE

There total 3 articles about N-CBZ-DL-HISTIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + D,L-histidine (71-00-1) → Nα-benzyloxycarbonyl-DL-histidine (19728-57-5)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; Ambient temperature;

DOI:10.1016/S0960-894X(97)00346-6

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + His (4998-57-6,26062-48-6,90081-11-1) → C14H15N3O4 (19728-57-5)

Guidance literature:

Reference yield:

→ Nα-benzyloxycarbonyl-DL-histidine (19728-57-5)

Guidance literature:

/BRN= 92342/;

upstream raw materials:

benzyl chloroformate

D,L-histidine

His

Downstream raw materials:

C₂₁H₂₉N₅O₅

amine protected histidine-NCA

Refernces

• 1、 Horwell,Kneen,Pritchard,Ratcliffe,Roberts,Suman-Chauhan,Steiner,Betche. "Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds.". . p. 1957 - 1962. Retrieved 2007/10/03.