Boc-lys(ME)2-OH

Base Information

• Chemical Name: Boc-lys(ME)2-OH
• CAS No.: 65671-53-6
• Molecular Formula: C13H26N2O4
• Molecular Weight: 274.36
• Hs Code.: 2924 19 00
• DSSTox Substance ID: DTXSID90427025
• Mol file: 65671-53-6.mol

Synonyms:BOC-LYS(ME)2-OH;65671-53-6;(2S)-6-(dimethylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid;(2S)-6-(Dimethylammonio)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)hexanoate;(2S)-2-{[(tert-butoxy)carbonyl]amino}-6-(dimethylamino)hexanoic acid;Nalpha-Boc-Nepsilon-dimethyl-L-lysine;Boc-Lys(Me2)-OH;Boc-Ne,e-dimethyl-L-lysine;SCHEMBL3004548;Boc-Lys(Me)2-OH, AldrichCPR;DTXSID90427025;KPXRFYHPDPDJSY-JTQLQIEISA-N;L-Lysine,N2-[(1,1-dimethylethoxy)carbonyl]-N6,N6-dimethyl-;(S)-2-(tert-Butoxycarbonylamino)-6-(dimethylamino)hexanoic acid;MFCD00076965;AKOS015998941;HY-W141982;AS-46939;CS-0201771;F10981;EN300-6472405;(S)-2-(Boc-amino)-6-(dimethylamino)hexanoic acid;N2-(tert-Butoxycarbonyl)-N6,N6-dimethyl-L-lysine;2(S)-(+)-tert-Butoxycarbonylamino-6-dimethylaminohexanoic acid;N-alpha-Boc-(S)-2-amino-6-(dimethylamino)hexanoic acid (Boc-Lys(Me2)-OH)

Chemical Property of Boc-lys(ME)2-OH

Chemical Property:

• Boiling Point: 413.3 °C at 760 mmHg
• Flash Point: 203.7 °C
• PSA: 78.87000
• Density: 1.064 g/cm³
• LogP: 2.08710
• Storage Temp.: -15°C
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 274.18925731
• Heavy Atom Count: 19
• Complexity: 298

Purity/Quality:

98%min ^*data from raw suppliers

Boc-Lys(Me)2-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCN(C)C)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCCCN(C)C)C(=O)O
• Uses: Boc-Lys(Me)2-OH is used in the synthesis of peptidyl α-keto thiazoles as tissue factor VIIa inhibitors. It is also used to prepare tetrahydropyranylglycine sulfonamides as bradykinin hB2 receptor antagonists.

Technology Process of Boc-lys(ME)2-OH

There total 1 articles about Boc-lys(ME)2-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Boc-Lys-OH (13734-28-6) → N2-(tert-butoxycarbonyl)-N6,N6-dimethyl-L-lysine (65671-53-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In water monomer; at 25 ℃; for 96h; under 2585.81 Torr;

Reference yield:

N2-(tert-butoxycarbonyl)-N6,N6-dimethyl-L-lysine (65671-53-6) + benzyl alcohol (100-51-6,185532-71-2) → (S)-benzyl 2-((tert-butoxycarbonyl)amino)-6-(dimethylamino)hexanoate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + N2-(tert-butoxycarbonyl)-N6,N6-dimethyl-L-lysine (65671-53-6) → methyl N2-(tert-butoxycarbonyl)-N6,N6-dimethyl-L-lysyl-L-phenylalaninate

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

upstream raw materials:

formaldehyd

Boc-Lys-OH

Downstream raw materials:

Fmoc-N^ε-(trimethyl)-L-lysine chloride

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR INHIBITING PROTEIN EMBRYONIC ECTODERM DEVELOPMENT ACTIVITY AND TREATING DISEASE". Paragraph 0886. . Retrieved 2021/10/02.
• 2、 -. "Quinazoline derivatives useful in cancer treatment". Page/Page column 223-224. . Retrieved 2010/11/25.