Technology Process of ethyl 5-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1,3,4-thiadiazole-2-carboxylate
There total 4 articles about ethyl 5-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1,3,4-thiadiazole-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
Isopropyl acetate;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h
3: toluene-4-sulfonic acid / Isopropyl acetate / 80 °C
With
hydrogen; potassium carbonate; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
ethanol; Isopropyl acetate; N,N-dimethyl-formamide;
3: Buckwald's amination;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h
3: toluene-4-sulfonic acid / Isopropyl acetate / 80 °C
With
hydrogen; potassium carbonate; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
ethanol; Isopropyl acetate; N,N-dimethyl-formamide;
3: Buckwald's amination;