6-FLUORO-1H-INDAZOL-3-YLAMINE

Base Information

• Chemical Name: 6-FLUORO-1H-INDAZOL-3-YLAMINE
• CAS No.: 404827-75-4
• Molecular Formula: C7H6FN3
• Molecular Weight: 151.143
• Hs Code.: 2933990090
• Mol file: 404827-75-4.mol

Synonyms:6-Fluoro-1H-indazol-3-ylamine;

Chemical Property of 6-FLUORO-1H-INDAZOL-3-YLAMINE

Chemical Property:

• Boiling Point: 379.288 °C at 760 mmHg
• Flash Point: 183.187 °C
• PSA: 54.70000
• Density: 1.488 g/cm³
• LogP: 1.86540
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

6-Fluoro-1h-indazol-3-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 6-FLUORO-1H-INDAZOL-3-YLAMINE

There total 3 articles about 6-FLUORO-1H-INDAZOL-3-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-[2-(diphenylmethylene)hydrazino]-4-fluorobenzonitrile (1219024-63-1) → 6-fluoro-1H-indazol-3-ylamine (404827-75-4)

Guidance literature:

2-[2-(diphenylmethylene)hydrazino]-4-fluorobenzonitrile; With water; toluene-4-sulfonic acid; In methanol; Reflux;

With sodium carbonate; In methanol;

DOI:10.1021/jo100243c

Reference yield: 44.7%

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) → 6-fluoro-1H-indazol-3-ylamine (404827-75-4)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; at 150 ℃; for 17h; Inert atmosphere;

Reference yield: 34.0%

→ 6-fluoro-1H-indazol-3-ylamine (404827-75-4)

Guidance literature:

With hydrazine; In butan-1-ol; at 110 ℃;

upstream raw materials:

2,4-difluorobenzonitrile

2-[2-(diphenylmethylene)hydrazino]-4-fluorobenzonitrile

Refernces

• 1、 -. "FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF". Paragraph 00316. . Retrieved 2018/11/10.
• 2、 -. "Compounds as syk kinase inhibitors". Paragraph 0300; 0301. . Retrieved 2013/03/26.