(R)-6-methylamino-2-methylheptene

Base Information

• Chemical Name: (R)-6-methylamino-2-methylheptene
• CAS No.: 1620401-56-0
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.257
• Mol file: 1620401-56-0.mol

Synonyms:(R)-6-methylamino-2-methylheptene

Chemical Property of (R)-6-methylamino-2-methylheptene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-methylamino-2-methylheptene

There total 6 articles about (R)-6-methylamino-2-methylheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-methanesulfonic acid 1,5-dimethyl-hex-4-enyl ester (1620401-61-7) + methylamine (74-89-5) → (R)-6-methylamino-2-methylheptene (1620401-56-0,65783-53-1)

Guidance literature:

In N,N-dimethyl acetamide; water; at 20 - 50 ℃; for 64h; Sealed tube;

Reference yield:

(R)-N-6-methylhept-5-en-2-amine (2S,3S)-2,3-bis((4-methylbenzoyl)oxy)succinate → (R)-6-methylamino-2-methylheptene (1620401-56-0,65783-53-1)

Guidance literature:

With sodium hydroxide; In tert-butyl methyl ether; water; at 20 - 25 ℃;

Reference yield:

3-methyl-2-butenylmagnesium chloride (35189-96-9) → (R)-6-methylamino-2-methylheptene (1620401-56-0,65783-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 5 - 20 °C

3: water; N,N-dimethyl acetamide / 64 h / 20 - 50 °C / Sealed tube

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;

upstream raw materials:

3-methyl-2-butenylmagnesium chloride

(S)-methanesulfonic acid 1,5-dimethyl-hex-4-enyl ester

methylamine

6-Methyl-hept-5-en-2-on

Downstream raw materials:

(R)-isometheptene mucate

(R)-isometheptene mucate

Refernces

• 1、 -. "NOVEL (R)-ISOMETHEPTENE COMPOSITIONS AND USES". Paragraph 0196-0197. . Retrieved 2016/01/22.