METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
• CAS No.: 65202-50-8
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.571
• Hs Code.: 29335990
• Mol file: 65202-50-8.mol

Synonyms:6-Chloropyridazine-3-carboxylicacid methyl ester;Methyl 6-chloropyridazine-3-carboxylate;

Chemical Property of METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 4.02E-08mmHg at 25°C
• Melting Point: 145 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 310.939 °C at 760 mmHg
• PKA: -1.06±0.10(Predicted)
• Flash Point: 141.851 °C
• PSA: 52.08000
• Density: 1.373 g/cm³
• LogP: 0.91660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-chloropyridazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE

There total 16 articles about METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ methyl 6-chloro-3-pyridazinecarboxylate (65202-50-8)

Guidance literature:

In dichloromethane; at 0 ℃; for 2h;

Reference yield: 88.2%

methanol (67-56-1) + 6-chloro-pyridazine-3-carboxylic acid (5096-73-1) → methyl 6-chloro-3-pyridazinecarboxylate (65202-50-8)

Guidance literature:

6-chloro-pyridazine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 1h;

methanol; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 79.0%

6-hydroxypyridazine-3-carboxylic acid methyl ester (63001-30-9) → methyl 6-chloro-3-pyridazinecarboxylate (65202-50-8)

Guidance literature:

With trichlorophosphate; for 2.5h; Reflux;

upstream raw materials:

6-chloro-pyridazine-3-carbonyl chloride

methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate

methanol

6-chloro-pyridazine-3-carboxylic acid

Downstream raw materials:

2-butyl-4-<6-(methoxycarbonyl)pyridazin-3-yl>-1-<<1'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>-1H-imidazole

methyl 6-methoxypyridazine-3-carboxylate

6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid methyl ester

methyl 3-[3-(5-bromopyrimidin-2-yl)benzyl]-1,2,4-triazolo[4,3-b]pyridazine-6-carboxylate

Refernces

• 1、 -. "HETEROARYL SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF". Page/Page column 327-328. . Retrieved 2022/02/15.
• 2、 -. "INHIBITOR COMPOUNDS". Page/Page column 63; 85; 90-91. . Retrieved 2021/01/29.