4,4-DIMETHYLCYCLOHEXYLAMINE

Base Information

• Chemical Name: 4,4-DIMETHYLCYCLOHEXYLAMINE
• CAS No.: 20615-18-3
• Molecular Formula: C8H17N
• Molecular Weight: 127.23
• Hs Code.: 2921300090
• Mol file: 20615-18-3.mol

Synonyms:Cyclohexylamine,4,4-dimethyl- (8CI);4,4-Dimethylcyclohexylamine;4,4-Dimethylcyclohexanamine;

Chemical Property of 4,4-DIMETHYLCYCLOHEXYLAMINE

Chemical Property:

• Vapor Pressure: 2.38mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 160.5 °C at 760 mmHg
• Flash Point: 30.2 °C
• PSA: 26.02000
• Density: 0.834 g/cm³
• LogP: 2.61420
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

4,4-Dimethylcyclohexan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4-DIMETHYLCYCLOHEXYLAMINE

There total 4 articles about 4,4-DIMETHYLCYCLOHEXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4,4-dimethylcyclohexan-1-one oxime (4701-96-6) → 4,4-dimethyl-1-cyclohexylamine (20615-18-3)

Guidance literature:

With hydrogen; nickel; In ethanol; for 96h; under 2585.81 Torr;

Reference yield:

4,4-dimethylcyclohexane-1-one (4255-62-3) → 4,4-dimethyl-1-cyclohexylamine (20615-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium carbonate / water; ethanol / 3 h / Reflux

2: nickel; hydrogen / ethanol / 16 h / 4137.29 Torr

With hydroxylamine hydrochloride; hydrogen; nickel; sodium carbonate; In ethanol; water;

Reference yield:

C15H23N → 4,4-dimethyl-1-cyclohexylamine (20615-18-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01852

upstream raw materials:

4,4-dimethylcyclohexan-1-one oxime

4,4-dimethylcyclohexane-1-one

Downstream raw materials:

NITD-304

Refernces

• 1、 Sch?fer, Christian,Ni?anci, Bilal,Bere, Matthew P.,Da?tan, Arif,T?r?k, Béla. "Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source". . p. 3127 - 3133. Retrieved 2016/09/09.
• 2、 -. "HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE". Page 78-79. . Retrieved 2010/02/07.