3-HYDROXY-4-METHYL-BENZALDEHYDE

Base Information

• Chemical Name: 3-HYDROXY-4-METHYL-BENZALDEHYDE
• CAS No.: 57295-30-4
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• Hs Code.: 2912499000
• Mol file: 57295-30-4.mol

Synonyms:3-Hydroxy-4-methylbenzaldehyde;3,4-Cresotaldehyde(7CI);

Chemical Property of 3-HYDROXY-4-METHYL-BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0121mmHg at 25°C
• Melting Point: 73-74 °C
• Refractive Index: 1.601
• Boiling Point: 252.4 °C at 760mmHg
• PKA: 9.59±0.10(Predicted)
• Flash Point: 104.1 °C
• PSA: 37.30000
• Density: 1.175 g/cm³
• LogP: 1.51310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydroxy-4-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-4-METHYL-BENZALDEHYDE

There total 11 articles about 3-HYDROXY-4-METHYL-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-methyl-3-nitrobenzaldehyde (31680-07-6) → 3-hydroxy-4-methylbenzaldehyde (57295-30-4)

Guidance literature:

4-methyl-3-nitrobenzaldehyde; With hydrogenchloride; tin(ll) chloride; at 5 - 100 ℃; for 1h;

at 90 ℃; for 3h;

With sodium nitrite; In water; for 1.5h; Cooling with ice;

DOI:10.1016/j.bmcl.2020.127342

Reference yield: 41.4%

3-methoxy-4-methylbenzaldehyde (24973-22-6) → 3-hydroxy-4-methylbenzaldehyde (57295-30-4)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 - 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.9b00270

Reference yield: 33.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-hydroxy-4-methylbenzyl alcohol (90953-62-1) → 7-hydroxy-6-methyl-1,3-dihydro-2-benzofuran-1-one (154550-07-9) + 3-hydroxy-4-methylbenzaldehyde (57295-30-4)

Guidance literature:

With tin(IV) chloride; triethylamine; In acetonitrile; for 17h; Heating;

DOI:10.1080/00397910500297214

upstream raw materials:

4-methyl-3-nitrobenzaldehyde

(3-Hydroxy-4-methyl-phenyl)-nitro-methan

6-acetoxy-3,6-dimethyl-cyclohexa-2,4-dienone

formaldehyd

Downstream raw materials:

3-Dodecyloxy-4-methylbenzaldehyd

3-Hexyloxy-4-methylbenzaldehyde

3-methoxy-4-methylbenzaldehyde

5-[(1Z)-1-hepten-1-yl]-2-methylphenol

Refernces

• 1、 -. "NOVEL BENZYLIDENEACETONE DERIVATIVE AND USE THEREOF". Paragraph 0117-0119. . Retrieved 2020/06/23.
• 2、 -. "Novel Compounds". . . Retrieved 2011/06/24.