6-(3-NITROPHENYL)-3(2H)-PYRIDAZINONE

Base Information

• Chemical Name: 6-(3-NITROPHENYL)-3(2H)-PYRIDAZINONE
• CAS No.: 54558-01-9
• Molecular Formula: C10H7N3O3
• Molecular Weight: 217.184
• Hs Code.: 2933990090
• Mol file: 54558-01-9.mol

Synonyms:3(2H)-Pyridazinone,6-(m-nitrophenyl)- (6CI);6-(3-Nitrophenyl)-3(2H)-pyridazinone;

Chemical Property of 6-(3-NITROPHENYL)-3(2H)-PYRIDAZINONE

Chemical Property:

• PSA: 91.57000
• Density: 1.461 g/cm³
• LogP: 1.86830

Purity/Quality:

99% ^*data from raw suppliers

6-(3-nitrophenyl)-2,3-dihydropyridazin-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(3-NITROPHENYL)-3(2H)-PYRIDAZINONE

There total 6 articles about 6-(3-NITROPHENYL)-3(2H)-PYRIDAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(m-Nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine (52239-76-6) → 3-(m-Nitrophenyl)-6-oxo-1,6-dihydropyridazine (54558-01-9)

Guidance literature:

With bromine; acetic acid; for 1h; Heating;

DOI:10.1021/jm00137a020

Reference yield: 85.0%

ethyl β-(o-nitrobenzoyl)lactate (1010448-64-2) → 3-(m-Nitrophenyl)-6-oxo-1,6-dihydropyridazine (54558-01-9)

Guidance literature:

With hydrazine; In butan-1-ol; Heating / reflux;

Reference yield:

3-(m-Nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine (52239-76-6) → 3-methyl-6-(3-nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazine (66548-74-1) + 3-(m-Nitrophenyl)-6-oxo-1,6-dihydropyridazine (54558-01-9)

Guidance literature:

With bromine; In acetic acid;

upstream raw materials:

3-(m-Nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine

Glyoxilic acid

3-Nitroacetophenone

ethyl β-(o-nitrobenzoyl)lactate

Downstream raw materials:

3-(m-Aminophenyl)pyridazine

6-(3-amino-phenyl)-2H-pyridazin-3-one

3-methyl-6-(3-acetamidophenyl)-1,2,4-triazolo<4,3-b>pyridazine

3-methyl-6-(3-nitrophenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Refernces

• 1、 Xu, Qile,Wang, Yueting,Xu, Jingwen,Sun, Maolin,Tian, Haiqiu,Zuo, Daiying,Guan, Qi,Bao, Kai,Wu, Yingliang,Zhang, Weige. "Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents". supporting information. p. 1202 - 1206. Retrieved 2016/12/18.
• 2、 -. "INHIBITORS OF C-MET AND USES THEREOF". Page/Page column 54. . Retrieved 2008/06/13.