6-Bromoindazole

Base Information

• Chemical Name: 6-Bromoindazole
• CAS No.: 79762-54-2
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 29339900
• Mol file: 79762-54-2.mol

Synonyms:6-Bromo-1H-indazole;

Chemical Property of 6-Bromoindazole

Chemical Property:

• Melting Point: 180-182 °C
• Boiling Point: 333.821 °C at 760 mmHg
• PKA: 12.78±0.40(Predicted)
• Flash Point: 155.69 °C
• PSA: 28.68000
• Density: 1.771 g/cm³
• LogP: 2.32540
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-36/37-39

MSDS Files:

Useful:

• Uses: 6-Bromo-1H-indazole is an indazole derivative being studied as an inhibitor of DNA gyrase B and its antibacterial activity.

Technology Process of 6-Bromoindazole

There total 10 articles about 6-Bromoindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-2-fluorobenzaldehyde (57848-46-1) → 6-bromo-1H-indazole (79762-54-2)

Guidance literature:

With hydrazine hydrate; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

Reference yield: 93.0%

1-(6-bromo-1H-indazol-1-yl)ethanone (651780-33-5) → 6-bromo-1H-indazole (79762-54-2)

Guidance literature:

With sodium hydroxide; In methanol; water; for 3h; Heating / reflux;

Reference yield: 88.0%

→ 6-bromo-1H-indazole (79762-54-2)

Guidance literature:

upstream raw materials:

5-bromo-2-methylaniline

4-bromo-2-fluorobenzaldehyde

6-amino-1H-indazole

copper

Downstream raw materials:

6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-indazole

2-benzyl-6-bromoindazole

1-(4-methoxybenzyl)-6-bromo-1H-indazole

1H-indazole-6-carboxyaldehyde

Refernces

• 1、 Wang, Xing-Rong,Wang, Shuai,Li, Wen-Bo,Xu, Kai-Yan,Qiao, Xue-Peng,Jing, Xue-Li,Wang, Zi-Xiao,Yang, Chang-jiang,Chen, Shi-Wu. "Design, synthesis and biological evaluation of novel 2-(4-(1H-indazol-6-yl)-1H-pyrazol-1-yl)acetamide derivatives as potent VEGFR-2 inhibitors". supporting information. . Retrieved 2021/01/26.
• 2、 -. "Micromolecular reversible BTK inhibitor for treating rheumatoid arthritis". Paragraph 0140-0144. . Retrieved 2019/07/29.