Technology Process of 6-[2-chloro-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-8-ethyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one
There total 11 articles about 6-[2-chloro-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-8-ethyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 5 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C
2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C
3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C
4: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C
5: sodium hydroxide / 4 h / Reflux
6: thionyl chloride / 1 h / Reflux
7: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C
8: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
9: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 5 - 20 °C
10: pyridine / 5 - 90 °C
11: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 5 - 20 °C
With
4-methyl-morpholine; pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; ISOPROPYLAMIDE; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl-ammonium chloride; water; phosphorus tribromide; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C
2: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C
3: sodium hydroxide / 4 h / Reflux
4: thionyl chloride / 1 h / Reflux
5: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C
6: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
7: hydroxylamine hydrochloride; potassium tert-butylate / dimethyl sulfoxide / 5 - 20 °C
8: pyridine / 5 - 90 °C
9: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 5 - 20 °C
With
pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; ISOPROPYLAMIDE; hydroxylamine hydrochloride; potassium tert-butylate; tetrabutyl-ammonium chloride; phosphorus tribromide; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;