2-Methoxyphenylmagnesium bromide

Base Information

• Chemical Name: 2-Methoxyphenylmagnesium bromide
• CAS No.: 16750-63-3
• Molecular Formula: C7H7BrMgO
• Molecular Weight: 211.341
• Hs Code.: 29319090
• European Community (EC) Number: 627-045-4
• Mol file: 16750-63-3.mol

Synonyms:16750-63-3;2-methoxyphenylmagnesium bromide;(2-methoxyphenyl)magnesium bromide;magnesium;methoxybenzene;bromide;2-methoxyphenylmagnesiumbromide;Magnesium, bromo(2-methoxyphenyl)-;MFCD01317003;2-Methoxyphenylmagnesium bromide, 1.0 M in THF;Magnesium, bromo(methoxyphenyl)-;2-methoxyphenyl magnesium bromide;SCHEMBL162625;o-methoxyphenylmagnesium bromide;bromo(2-methoxyphenyl)magnesium;2-methoxylphenylmagnesium bromide;2-methoxyphenyl-magnesium bromide;BJJFGIPCBFILPB-UHFFFAOYSA-M;2-methoxy phenyl magnesium bromide;ortho-methoxyphenyl magnesium bromide;AKOS015911491;2-Methoxyphenylmagnesium bromide, 0.5 M in THF;2-Methoxyphenylmagnesium bromide, 1.0 M in 2-MeTHF;2-Methoxyphenylmagnesium bromide 0.5 M in Diethyl Ether;2-Methoxyphenylmagnesium bromide 0.5 M in Tetrahydrofuran

Chemical Property of 2-Methoxyphenylmagnesium bromide

Chemical Property:

• Boiling Point: 65-67 °C
• Flash Point: -4 °F
• PSA: 9.23000
• Density: 1.011 g/mL at 25 °C
• LogP: 2.34100
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.95307
• Heavy Atom Count: 10
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxyphenylmagnesium bromide solution 1.0 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+;C;F
• Hazard Codes: F+,C,F,Xn
• Statements: 12-14-19-22-34-66-67-20/21/22-11-36/37-40
• Safety Statements: 16-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=[C-]1.[Mg+2].[Br-]
• Uses: 2-Methoxyphenylmagnesium Bromide is used in the versatile synthesis of O-desmethylangolensin analogs from methoxy-substituted benzoic acids.

Technology Process of 2-Methoxyphenylmagnesium bromide

There total 8 articles about 2-Methoxyphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl acetate n-hexane + 2-bromoanisole (578-57-4) + imidazol-1-yl-oxo-acetic acid ethyl ester (75716-82-4) → ethyl (2-methoxyphenyl)(oxo)acetate (66644-69-7) + 2-methoxyphenylmagnesium bromide (16750-63-3)

Guidance literature:

Reference yield:

2-bromoanisole (578-57-4) → 2-methoxyphenylmagnesium bromide (16750-63-3)

Guidance literature:

With magnesium; In tetrahydrofuran; for 0.00833333h; Sonographic reaction;

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) + 2-bromoanisole (578-57-4) → 2-methoxyphenylmagnesium bromide (16750-63-3)

Guidance literature:

With ammonium chloride; magnesium; In tetrahydrofuran;

upstream raw materials:

2-bromoanisole

5-amino-4-cyano-3-methylthio-1-(2,4,6-trichlorophenyl)pyrazole

5-chloroindole 2,3-dione

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

Downstream raw materials:

3-(2-Methoxybenzoyl)naphthalin-2-carbonsaeure

3-(2-methoxyphenyl)pyridine

2-Acetamino-4-fluoro-2'-methoxybenzophenone

2-Amino-1-(2-methoxyphenyl)-2-methyl-1-propanol

Refernces

• 1、 -. "OLIGOMERISATION OF ETHYLENE TO MIXTURES OF 1-HEXENE AND 1-OCTENE". Page/Page column 32-33. . Retrieved 2014/12/09.
• 2、 Alorati, Anthony D.,Gibb, Andrew D.,Mullens, Peter R.,Stewart, Gavin W.. "An efficient process for the large-scale synthesis of a 2,3,6-trisubstituted indole". . p. 1947 - 1952. Retrieved 2013/03/14.