2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine

Base Information

• Chemical Name: 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine
• CAS No.: 1197953-49-3
• Molecular Formula: C₁₂H₁₂Cl₂N₃OP
• Molecular Weight: 316.127
• Mol file: 1197953-49-3.mol

Synonyms:(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

Chemical Property of 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine

Chemical Property:

• Boiling Point: 527.5±50.0 °C(Predicted)
• PKA: 0.30±0.10(Predicted)
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.0%, High purity. ^*data from raw suppliers

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine

There total 7 articles about 2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

(2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1) + 2,4,5-trichloropyrimidine (5750-76-5) → (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (1197953-49-3)

Guidance literature:

With dipotassium hydrogenphosphate; In N,N-dimethyl-formamide; at 65 ℃; for 4h;

Reference yield: 79.0%

(2-aminophenyl)dimethylphosphine oxide hydrochloride + 2,4,5-trichloropyrimidine (5750-76-5) → (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (1197953-49-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃; for 18h; Large scale;

Reference yield:

2-iodophenylamine (615-43-0) → (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (1197953-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

With potassium phosphate; potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide;

upstream raw materials:

2-iodophenylamine

(2-aminophenyl)dimethyl phosphorus oxide

2,4,5-trichloropyrimidine

tert-butyl 2-iodophenylcarbamate

Downstream raw materials:

C₁₈H₂₅ClN₅OP

(2-((5-chloro-2-((4-fluoro-2-methoxy-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

C₂₄H₂₇ClN₅O₆P

C₁₉H₂₁ClN₅O₂P

Refernces

• 1、 Ding, Jian,Ding, Ke,Lai, Mengzhen,Lei, Chong,Li, Shan,Lu, Xiaoyun,Pang, Zilu,Peng, Lijie,Ren, Xiaomei,Tong, Linjiang,Xie, Hua,Yun, Cai-Hong,Zhang, Tao,Zhu, Su-Jie. "Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797SMutants". . . Retrieved 2022/02/07.
• 2、 -. "EGFR INHIBITORS, COMPOSITIONS AND METHODS THEREOF". Page/Page column 33. . Retrieved 2020/07/31.