3-Bromo-6-methoxy-2-methylpyridine

Base Information

• Chemical Name: 3-Bromo-6-methoxy-2-methylpyridine
• CAS No.: 126717-59-7
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• European Community (EC) Number: 640-603-1
• DSSTox Substance ID: DTXSID40445017
• Nikkaji Number: J582.099E
• Wikidata: Q72446366
• Mol file: 126717-59-7.mol

Synonyms:126717-59-7;3-bromo-6-methoxy-2-methylpyridine;5-Bromo-2-methoxy-6-picoline;3-Bromo-6-methoxy-2-picoline;3-bromo-6-methoxy-2-methyl-pyridine;Pyridine, 3-bromo-6-methoxy-2-methyl-;5-Bromo-2-methoxy-6-methylpyridine;5-Bromo-6-methyl-2-methoxypyridine;MFCD03094943;5-Bromo-2-methoxy-6-methyl pyridine;2-methoxy-5-bromo-6-picoline;2-METHOXY-5-BROMO-6-METHYLPYRIDINE;SCHEMBL1461146;DTXSID40445017;VWNXCCTWVAQAPL-UHFFFAOYSA-N;BCP22173;6-methoxy-3-bromo-2-methylpyridine;AKOS015852269;AB13393;AC-5411;CS-W003010;FS-2162;SY017584;3-Bromo-6-methoxy-2-methylpyridine, 95%;3-Bromo-6-methoxy-2-picoline, AldrichCPR;A2656;AM20070006;B4460;FT-0650028;EN300-98670;W-205256;Z1269168181

Chemical Property of 3-Bromo-6-methoxy-2-methylpyridine

Chemical Property:

• Vapor Pressure: 0.25mmHg at 25°C
• Refractive Index: n20/D 1.548
• Boiling Point: 212.591 °C at 760 mmHg
• PKA: 1.76±0.10(Predicted)
• Flash Point: 82.372 °C
• PSA: 22.12000
• Density: 1.452 g/cm³
• LogP: 2.16110
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-6-methoxy-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 41-22
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)OC)Br

Technology Process of 3-Bromo-6-methoxy-2-methylpyridine

There total 11 articles about 3-Bromo-6-methoxy-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 3-bromo-6-methoxy-2-methylpyridine (126717-59-7)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In tetrahydrofuran; for 72h;

DOI:10.1016/S0040-4020(00)00227-1

Reference yield: 96.0%

sodium methylate (124-41-4) + 2,5-dibromo-6-methylpyridine (39919-65-8) → 3-bromo-6-methoxy-2-methylpyridine (126717-59-7)

Guidance literature:

In methanol; at 65 - 75 ℃; for 6h;

Reference yield: 95.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 3-bromo-6-methoxy-2-methylpyridine (126717-59-7) + 3-bromo-2-methoxy-6-methylpyridine (717843-47-5)

Guidance literature:

With disodium hydrogenphosphate; bromine; In water; at 20 ℃; for 4h;

DOI:10.1039/c3dt52739e

upstream raw materials:

2-methoxy-6-methyl-pyridine

5-bromo-6-methyl-1,2-dihydropyridin-2-one

methyl iodide

6-hydroxy-2-methylpyridine

Downstream raw materials:

1-(6-Methoxy-2-methyl-pyridin-3-yl)-cyclohex-2-enol

4-methoxy-phenol

1-(6-methoxy-2-methylpyridin-3-yl)cyclohex-3-enol

C₁₇H₂₀BrNO₂

Refernces

• 1、 Ding, Rui,Lu, Yunyu,Yao, Hequan,Sun, Bingfeng,Lin, Guoqiang. "A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation". scheme or table. p. 1097 - 1100. Retrieved 2012/08/28.
• 2、 -. "1,2,4-oxadiazole derivatives and their therapeutic use". Page/Page column 54. . Retrieved 2010/07/08.