(S)-2-AMINO-3-CYCLOHEXYL-PROPAN-1-OL

Base Information

• Chemical Name: (S)-2-AMINO-3-CYCLOHEXYL-PROPAN-1-OL
• CAS No.: 131288-67-0
• Molecular Formula: C9H19NO
• Molecular Weight: 157.256
• Hs Code.: 2922199090
• Mol file: 131288-67-0.mol

Synonyms:S-(+)-2-Amino-3-cyclohexyl-1-propanol;((S)-1-(Cyclohexylmethyl)-2-hydroxyethyl)amine;(S)-2-Amino-3-cyclohexyl-1-propanol;Cyclohexanepropanol,b-amino-, (S)-;(+)-(2S)-2-Amino-3-cyclohexyl-1-propanol;

Chemical Property of (S)-2-AMINO-3-CYCLOHEXYL-PROPAN-1-OL

Chemical Property:

• Boiling Point: 289.5 °C at 760 mmHg
• PKA: 12.86±0.10(Predicted)
• Flash Point: 128.9 °C
• PSA: 46.25000
• Density: 0.97 g/cm³
• LogP: 1.97670
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.3% ^*data from raw suppliers

(S)-2-Amino-3-cyclohexylpropan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-3-CYCLOHEXYL-PROPAN-1-OL

There total 6 articles about (S)-2-AMINO-3-CYCLOHEXYL-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate (103322-56-1) → (2S)-2-amino-3-cyclohexyl-1-propanol (131288-67-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h;

Reference yield: 70.0%

L-cyclohexylalanine (27527-05-5) → (2S)-2-amino-3-cyclohexyl-1-propanol (131288-67-0)

Guidance literature:

With borane-THF;

DOI:10.1002/ejoc.200390129

Reference yield: 43.0%

L-Phenylalaninol (3182-95-4) → (2S)-2-amino-3-cyclohexyl-1-propanol (131288-67-0)

Guidance literature:

With hydrogenchloride; hydrogen; Rh/Al₂O₃; In water; at 20 ℃; under 750.06 Torr;

DOI:10.1080/00397910008087034

upstream raw materials:

tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate

L-cyclohexylalanine

L-Phenylalaninol

methyl (2S)-2-amino-3-phenylpropanoate

Downstream raw materials:

tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate

(-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide

(S)-5-Cyclohexylmethyl-2-oxo-morpholine-4-carboxylic acid tert-butyl ester

ethyl N-<4-(2(S)-3-cyclohexyl-1-hydroxypropan-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Refernces

• 1、 Strotmann,Butenschon. "Catalytic hydrogenation of aromatic amines at atmospheric pressure in water". . p. 4173 - 4176. Retrieved 2000.
• 2、 -. "CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT". Page/Page column 35. . Retrieved 2008/06/13.