1-(1-Methyl-4-piperidinyl)piperazine

Base Information

• Chemical Name: 1-(1-Methyl-4-piperidinyl)piperazine
• CAS No.: 23995-88-2
• Molecular Formula: C10H21N3
• Molecular Weight: 183.297
• Hs Code.: 29335990
• European Community (EC) Number: 607-300-6
• DSSTox Substance ID: DTXSID80340653
• Wikidata: Q72495960
• Mol file: 23995-88-2.mol

Synonyms:23995-88-2;1-(1-Methyl-4-piperidinyl)piperazine;1-(1-methylpiperidin-4-yl)piperazine;1-(n-methylpiperidin-4-yl)piperazine;1-(1-Methyl-piperidin-4-yl)-piperazine;Piperazine, 1-(1-methyl-4-piperidinyl)-;MFCD01075186;1-Methyl-4-piperazinopiperidine;1-(1-Methyl-4-piperidino)piperazine;SCHEMBL105570;DTXSID80340653;1-(1-methyl-4-piperidyl)piperazine;STK503368;1-(N-methyl-4-piperidyl)-piperazine;1-(1-methyl-4-piperidinyl)piperizine;4-(1-methylpiperidin-4-yl)piperazine;AKOS005171545;1-(1-methylpiperidin-4-yl)-piperazin;PS-5070;1-(1-methyl-4-piperi-dinyl)piperazine;1-(1-methyl-4-piperidinyl)-piperazine;1-(1-methyl-piperidin-4-yl)-piperazin;1-(1-methyl-piperidin-4-yl)piperazine;1-(1-methylpiperidin-4-yl)-piperazine;1-(N-Methyl-piperidin-4-yl)piperazine;1-(1-methylpiperidine-4-yl)-piperazine;Piperazine, 1-(1-methyl-4-piperidyl)-;1-(1-Methyl-4-piperidinyl)piperazine #;BB 0261088;CS-0145448;FT-0638375;EN300-1852263;1-(1-Methyl-4-piperidinyl)piperazine, >=98.0% (GC)

Chemical Property of 1-(1-Methyl-4-piperidinyl)piperazine

Chemical Property:

• Vapor Pressure: 0.0124mmHg at 25°C
• Melting Point: 29-32℃
• Refractive Index: n20/D 1.508
• Boiling Point: 260.3 °C at 760 mmHg
• PKA: 9.28±0.10(Predicted)
• Flash Point: 113.2 °C
• PSA: 18.51000
• Density: 0.992 g/cm3
• LogP: 0.19040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 183.173547683
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(1-Methylpiperidin-4-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C; Xi
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)N2CCNCC2
• Uses: 1-(1-Methylpiperidin-4-yl)piperazine is used in preparation of Pyrazolo Estratrienes as inhibitors of 17-HSD1.

Technology Process of 1-(1-Methyl-4-piperidinyl)piperazine

There total 4 articles about 1-(1-Methyl-4-piperidinyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

1-benzyl-4-(1-methylpiperidin-4-yl)piperazine → 1-(1-methyl-piperidin-4-yl)-piperazine (23995-88-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 2h; under 3750.38 Torr;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + 1-phenylmethylpiperazine (2759-28-6) → 1-(1-methyl-piperidin-4-yl)-piperazine (23995-88-2)

Guidance literature:

With sodium cyanoborohydride; palladium; In methanol;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → 1-(1-methyl-piperidin-4-yl)-piperazine (23995-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 3750.38 Torr

With palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane;

upstream raw materials:

1-Methyl-4-piperidone

1-phenylmethylpiperazine

Downstream raw materials:

N-[5-cyano-1-[(2,4-dimethoxyphenyl)sulphonyl]-3-(2-ethoxypyridin-3-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-(1-methylpiperidin-4-yl)piperazine-1-carboxamide

{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butylester

4-methoxy-N,2,6-trimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide monotrifluoroacetate

4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide

Refernces

• 1、 -. "Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation". . . Retrieved 2008/06/13.