N,N'-dibenzhydrylethane-1,2-diamine

Base Information

• Chemical Name: N,N'-dibenzhydrylethane-1,2-diamine
• CAS No.: 83027-13-8
• Molecular Formula: C28H30Cl2N2
• Molecular Weight: 392.544
• Hs Code.: 2921590090
• DSSTox Substance ID: DTXSID801320362
• Nikkaji Number: J1.762.655H
• Wikidata: Q106045160
• ChEMBL ID: CHEMBL1387826
• Mol file: 83027-13-8.mol

Synonyms:N,N'-dibenzhydrylethane-1,2-diamine;83027-13-8;AMN082 (free base);AMN-082;MLS001173561;AMN 082;SMR000538659;benzhydryl-[2-(benzhydrylamino)ethyl]amine;N,N inverted exclamation marka-bis(diphenylmethyl)-1,2-ethanediamine;D02ETA;GTPL1441;SCHEMBL8095249;CHEMBL1387826;N,N'-Dibenzhydrylethylenediamine;BDBM58360;CHEBI:92409;cid_1894361;DTXSID801320362;HMS2873J07;HMS3745A15;STL321288;AKOS003669868;HY-103565A;N,N''-dibenzhydrylethane-1,2-diamine;SDCCGSBI-0633765.P001;NCGC00092383-02;NCGC00092383-03;NCGC00092383-04;MS-26574;CS-0083114;N,N'-bis(diphenylmethyl)ethane-1,2-diamine;N,N''-bis(diphenylmethyl)ethane-1,2-diamine;N1,N2-DIBENZHYDRYLETHANE-1,2-DIAMINE;F81803;N,N'-bis[di(phenyl)methyl]ethane-1,2-diamine;BRD-K23335153-300-01-7

Chemical Property of N,N'-dibenzhydrylethane-1,2-diamine

Chemical Property:

• Boiling Point: 533.7 °C at 760 mmHg
• Flash Point: 321.5 °C
• PSA: 24.06000
• LogP: 8.13060
• Storage Temp.: Desiccate at +4°C
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 392.225248902
• Heavy Atom Count: 30
• Complexity: 362

Purity/Quality:

98%Min ^*data from raw suppliers

AMN 082 dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4
• Uses: AMN082 dihydrochloride is a selective agonist at mGluR-7.

Technology Process of N,N'-dibenzhydrylethane-1,2-diamine

There total 6 articles about N,N'-dibenzhydrylethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N1,N2-dibenzhydrylethane-1,2-diimine (141734-22-7) → N,N'-bis(diphenylmethyl)-1,2-ethanediamine (83027-13-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03061

Reference yield: 54.2%

N,N'-bis(α-phenylbenzylidene)ethylenediamine (64042-50-8) → benzophenone (119-61-9) + N,N'-bis(diphenylmethyl)-1,2-ethanediamine (83027-13-8)

Guidance literature:

In N,N-dimethyl-formamide; electrochemical reduction at -3.1- to -3.20 V;

DOI:10.1021/jo00144a010

Reference yield:

N,N'-bis(α-phenylbenzylidene)ethylenediamine (64042-50-8) → N,N'-bis(diphenylmethyl)-1,2-ethanediamine (83027-13-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 13.5h; Reflux;

DOI:10.1016/j.molstruc.2018.11.038

upstream raw materials:

N,N'-bis(benzyliden)ethylendiamine

N,N'-bis(α-phenylbenzylidene)ethylenediamine

benzophenone

ethylenediamine

Downstream raw materials:

1,3-dibenzhydrylimidazolinium chloride

Refernces

• 1、 Yi?it, Beyhan,Kaya, Ruya,Taslimi, Parham,I??k, Y?lmaz,Karaman, Muhammet,Yi?it, Murat,?zdemir, ?smail,Gul?in, ?lhami. "Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition". . p. 709 - 718. Retrieved 2019/01/05.
• 2、 Koch, Russell W.,Dessy, Raymond E.. "Electrochemical Reduction of Di-Schiff Bases. Synthesis of Piperazines, Indoloindoles, Diazepines, and Diazocines". . p. 4452 - 4459. Retrieved 2007/10/02.