4-Benzyloxy-2-methoxybenzaldehyde

Base Information

• Chemical Name: 4-Benzyloxy-2-methoxybenzaldehyde
• CAS No.: 58026-14-5
• Molecular Formula: C15H14 O3
• Molecular Weight: 242.274
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID90401643
• Nikkaji Number: J1.077.188I
• Wikidata: Q69755219
• Mol file: 58026-14-5.mol

Synonyms:58026-14-5;4-Benzyloxy-2-methoxybenzaldehyde;4-(Benzyloxy)-2-methoxybenzaldehyde;2-methoxy-4-phenylmethoxybenzaldehyde;Benzaldehyde, 2-methoxy-4-(phenylmethoxy)-;MFCD01075699;SCHEMBL435043;DTXSID90401643;HZLNIOUBXRIFML-UHFFFAOYSA-N;4-benzyloxy-2-methoxy-benzaldehyde;AKOS005207058;CS-W012778;DS-16452;FT-0600837;4-(Benzyloxy)-2-methoxybenzaldehyde, AldrichCPR;A831705;J-513645

Chemical Property of 4-Benzyloxy-2-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 5.28E-07mmHg at 25°C
• Melting Point: 98-100oC
• Boiling Point: 180°C 2mm
• Flash Point: 180°C/2mm
• PSA: 35.53000
• Density: 1.154g/cm³
• LogP: 3.08670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 248

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzyloxy-2-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)OCC2=CC=CC=C2)C=O

Technology Process of 4-Benzyloxy-2-methoxybenzaldehyde

There total 11 articles about 4-Benzyloxy-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl iodide (74-88-4) + 4-benzoxy-salicylaldehyde (52085-14-0) → 4-(benzyloxy)-2-methoxybenzaldehyde (58026-14-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1039/a901456j

Reference yield: 95.7%

4-hydroxy-2-methoxybenzaldehyde (18278-34-7) + benzyl bromide (100-39-0) → 4-(benzyloxy)-2-methoxybenzaldehyde (58026-14-5)

Guidance literature:

4-hydroxy-2-methoxybenzaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; for 1.5h; Inert atmosphere;

DOI:10.3390/molecules200915966

Reference yield: 93.0%

4-hydroxy-2-methoxybenzaldehyde (18278-34-7) + benzyl chloride (100-44-7) → 4-(benzyloxy)-2-methoxybenzaldehyde (58026-14-5)

Guidance literature:

4-hydroxy-2-methoxybenzaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

benzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1.16667h; Reflux;

DOI:10.1055/s-0040-1707257

upstream raw materials:

benzyl chloride

2,4-Dihydroxybenzaldehyde

methyl iodide

4-hydroxy-2-methoxybenzaldehyde

Downstream raw materials:

4-(benzyloxy)-2-methoxyphenol

4-(benzyloxy)-2-methoxy-1-vinylbenzene

diethyl [4-(benzyloxy)-2-methoxybenzylidene]propanedioate

3-cyano-3-{2-methoxy-4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Refernces

• 1、 -. "SMALL MOLECULES FOR TREATING CANCER, INHIBITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH". Page/Page column 8; 61-62. . Retrieved 2020/11/30.
• 2、 Zhang, Li,Hou, Lin,Sun, Wenyan,Yu, Zidong,Wang, Jibo,Gao, Hua,Yang, Guiming. "Synthesis of p-O-Alkyl Salicylanilide Derivatives as Novel EGFR Inhibitors". . p. 37 - 42. Retrieved 2016/02/23.