Methyl indolizine-1-carboxylate

Base Information

• Chemical Name: Methyl indolizine-1-carboxylate
• CAS No.: 316375-85-6
• Molecular Formula: C10H9 N O2
• Molecular Weight: 175.187
• Mol file: 316375-85-6.mol

Synonyms:Methylindolizine-1-carboxylate

Chemical Property of Methyl indolizine-1-carboxylate

Chemical Property:

• Density: 1.16

Purity/Quality:

99% ^*data from raw suppliers

Indolizine-1-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl indolizine-1-carboxylate

There total 6 articles about Methyl indolizine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(carboxymethyl)pyridinium chloride (6266-23-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl indolizine-1-carboxylate (316375-85-6)

Guidance literature:

With manganese(IV) oxide; triethylamine; In toluene; at 90 ℃; for 2h;

DOI:10.1055/s-2000-8195

Reference yield: 26.0%

N-(hydroxycarbonylmethyl)pyridinium bromide (45811-13-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl indolizine-1-carboxylate (316375-85-6)

Guidance literature:

Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201500957

Reference yield:

1-(carboxymethyl)-1,2-dihydropyridinium bromide + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl indolizine-1-carboxylate (316375-85-6)

Guidance literature:

With manganese(IV) oxide; triethylamine; In toluene; at 90 ℃; for 3h;

upstream raw materials:

1-(carboxymethyl)pyridinium chloride

acrylic acid methyl ester

pyridine

N-(hydroxycarbonylmethyl)pyridinium bromide

Downstream raw materials:

methyl 3-(phenylethynyl)indolizine-1-carboxylate

indolizino[3,4,5-ab]isoindole-2-carboxylic acid methyl ester

C₁₀H₈ClNO₂

methyl 3-(4-methylphenyl)indolizine-1-carboxylate

Refernces

• 1、 -. "INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". . . Retrieved 2016/07/27.
• 2、 -. "PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". . . Retrieved 2015/02/19.