2-(Pentafluoroethyl)benzimidazole

Base Information

• Chemical Name: 2-(Pentafluoroethyl)benzimidazole
• CAS No.: 383-08-4
• Molecular Formula: C9H5 F5 N2
• Molecular Weight: 236.144
• Hs Code.: 2933990090
• Mol file: 383-08-4.mol

Synonyms:1H-Benzimidazole,2-(pentafluoroethyl)- (9CI); Benzimidazole, 2-(pentafluoroethyl)-(6CI,7CI,8CI); 2-(Pentafluoroethyl)-1H-benzimidazole;2-(Pentafluoroethyl)benzimidazole

Chemical Property of 2-(Pentafluoroethyl)benzimidazole

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Boiling Point: 268.6°C at 760 mmHg
• Flash Point: 116.3°C
• PSA: 28.68000
• Density: 1.513g/cm³
• LogP: 3.21700

Purity/Quality:

98%min ^*data from raw suppliers

2-(Pentafluoroethyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Pentafluoroethyl)benzimidazole

There total 2 articles about 2-(Pentafluoroethyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

trans/cis-dodecafluoro-3,4-epoxyhexane (74728-99-7) + 1,2-diamino-benzene (95-54-5) → 2,3-bis(pentafluoroethyl)quinoxaline + 2-(1,1,2,2,2-pentafluoroethyl)-1H-benzimidazole (383-08-4) + 2-heptafluoropropyl-1H-benzoimidazole (559-37-5) + 3-pentafluoroethylquinoxalin-2(1H)-one (89995-28-8)

Guidance literature:

In N,N-dimethyl acetamide; for 2.5h; Heating;

DOI:10.1016/j.jfluchem.2005.05.001

Reference yield: 30.0%

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) + 1,2-diamino-benzene (95-54-5) → 2-(1,1,2,2,2-pentafluoroethyl)-1H-benzimidazole (383-08-4) + 2,2,3,3,3-pentafluoro-N-[2-(2,2,2-trifluoro-1-trifluoromethylethylamino)phenyl]propanamide (1429425-43-3)

Guidance literature:

In acetonitrile; at 80 ℃; for 5h; Cooling with ice;

DOI:10.1134/S1070428013030068

Reference yield: 66.0%

2-(1,1,2,2,2-pentafluoroethyl)-1H-benzimidazole (383-08-4) → 4,5,6,7-tetrachloro-2-pentafluoroethyl-1H-benzimidazole (49615-25-0)

Guidance literature:

With hydrogenchloride; nitric acid; In water; at 60 ℃; for 28h; Reflux;

DOI:10.1002/jhet.936

upstream raw materials:

trans/cis-dodecafluoro-3,4-epoxyhexane

1,2-diamino-benzene

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane

Downstream raw materials:

4,5,6,7-tetrachloro-2-pentafluoroethyl-1H-benzimidazole

Refernces

• 1、 Saloutina,Zapevalov,Saloutin,Kodess,Kirichenko,Pervova,Chupakhin. "Reactions of epoxides derived from internal perfluoroolefins with o-phenylenediamine and 2-aminophenol". . p. 558 - 566. Retrieved 2007/10/03.