N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile

Base Information

• Chemical Name: N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile
• CAS No.: 104586-59-6
• Molecular Formula: C₁₄H₁₁F₃N₂O
• Molecular Weight: 280.249
• Mol file: 104586-59-6.mol

Synonyms:N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile

Chemical Property of N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile

There total 1 articles about N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-amino-4-trifluoromethylbenzonitrile (1483-54-1) + 1,3-cylohexanedione (504-02-9) → N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile (104586-59-6)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 2h; Heating;

DOI:10.1021/jm00128a024

Reference yield:

N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile (104586-59-6) → 9-benzylamino-3,4-dihydro-6-trifluoromethylacridin-1(2H)-one (104586-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / K₂CO₃ / CuCl / tetrahydrofuran / 5 h / Heating

2: 58 percent / NaOH / 4N>4> / CH₂Cl₂; H₂O / 4 h

With sodium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; copper(l) chloride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm00128a024

Reference yield:

N-(3-oxo-cyclohexen-1-yl)-2-amino-4-trifluoromethylbenzonitrile (104586-59-6) → 9-benzylamino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol (104628-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / K₂CO₃ / CuCl / tetrahydrofuran / 5 h / Heating

2: 58 percent / NaOH / 4N>4> / CH₂Cl₂; H₂O / 4 h

3: 57 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h

With sodium hydroxide; lithium aluminium tetrahydride; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; copper(l) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1021/jm00128a024

upstream raw materials:

2-amino-4-trifluoromethylbenzonitrile

1,3-cylohexanedione

Downstream raw materials:

9-Amino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol

9-benzylamino-3,4-dihydro-6-trifluoromethylacridin-1(2H)-one

9-benzylamino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol

Refernces