N,N-Diisopropylmethylamine

Base Information

• Chemical Name: N,N-Diisopropylmethylamine
• CAS No.: 10342-97-9
• Molecular Formula: C7H17 N
• Molecular Weight: 115.219
• Hs Code.: 29211999
• European Community (EC) Number: 600-434-6
• DSSTox Substance ID: DTXSID20338190
• Nikkaji Number: J121.774G
• Wikidata: Q72467467
• Mol file: 10342-97-9.mol

Synonyms:N,N-Diisopropylmethylamine;10342-97-9;N-Methyldiisopropylamine;Diisopropylmethylamine;N-methyl-N-propan-2-ylpropan-2-amine;Methyldiisopropylamine;Diethylamine, N,1,1'-trimethyl-;2-Propanamine, N-methyl-N-(1-methylethyl)-;N-isopropyl-N-methylpropan-2-amine;DIPMA;diisopropylaminomethane;diisopropyl methylamine;Diisopropyl-methyl-amine;N,N-Diisopropylmethyamine;methylbis(propan-2-yl)amine;SCHEMBL43239;n,n-diisopropyl-n-methylamine;SCHEMBL9844746;DTXSID20338190;MFCD00048281;AKOS015850702;N-Isopropyl-N-methyl-2-propanamine #;FT-0625001;N,N-Diisopropylmethylamine, >=98.0% (GC);J-000964

Chemical Property of N,N-Diisopropylmethylamine

Chemical Property:

• Vapor Pressure: 44.9mmHg at 25°C
• Melting Point: -91.17°C (estimate)
• Refractive Index: n20/D 1.411(lit.)
• Boiling Point: 95.7°Cat760mmHg
• PKA: 10.90±0.28(Predicted)
• Flash Point: 10 ºC
• PSA: 3.24000
• Density: 0.754
• LogP: 1.73500
• Storage Temp.: Flammables area
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 115.136099547
• Heavy Atom Count: 8
• Complexity: 49.4

Purity/Quality:

99% ^*data from raw suppliers

N,N-Diisopropylmethylamine ≥98.0% (GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C
• Statements: 11-34-10
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(C)C(C)C

Technology Process of N,N-Diisopropylmethylamine

There total 14 articles about N,N-Diisopropylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + diisopropylamine (108-18-9) → N,N-diisopropylmethylamine (10342-97-9)

Guidance literature:

chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); at 100 ℃;

Reference yield: 92.0%

N,N-diisorpopylformamide (2700-30-3) → N,N-diisopropylmethylamine (10342-97-9)

Guidance literature:

With hydrogen; hexarhodium hexadecacarbonyl; decacarbonyldirhenium⁽⁰⁾; In 1,2-dimethoxyethane; at 160 ℃; for 16h; under 76000 Torr;

DOI:10.1016/S0040-4039(96)01458-X

Reference yield: 90.0%

Tetra-isopropyl-2-tetrazen (13304-31-9) → N,N-diisopropylmethylamine (10342-97-9) + N-ethylidene-N-isopropyl amine (27719-14-8)

Guidance literature:

at 400 ℃; under 0.0008 Torr;

upstream raw materials:

formaldehyd

diisopropylamine

methylamine

isopropyl bromide

Downstream raw materials:

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-3(E)-chloro-2-propenamide

(cyanomethyl)diisopropylmethylammonium tosylate

N-cyanomethyl-N,N-diisopropylamine

Refernces

• 1、 Ram, Siya,Ehrenkaufer, Richard E.. "RAPID REDUCTIVE-CARBOXYLATION OF SECONDARY AMINES. ONE POT SYNTHESIS OF TERTIARY N-METHYLATED AMINES". . p. 5367 - 5370. Retrieved 1985.
• 2、 Murdock,Angier. "-". . p. 3748,3755. Retrieved 1962.
• 3、 Ge, Xin,Luo, Chenxi,Qian, Chao,Yu, Zhiping,Chen, Xinzhi. "RANEY nickel-catalyzed reductive N-methylation of amines with paraformaldehyde: Theoretical and experimental study". . p. 43195 - 43203. Retrieved 2014.
• 4、 Kostyanovskii, R. G.,Shakhgel'diev, M. A.,Nabiev, O. G.. "STERIC PROHIBITION FOR THE FORMATION OF AMINALS FROM DI-SEC-ALKYLAMINES AND DI-TERT-ALKYLAMINES". . p. 2593. Retrieved 1986.
• 5、 Benaissa, Idir,Cantat, Thibault,Genre, Caroline,Godou, Timothé,Pinault, Mathieu. "Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst". . p. 57 - 61. Retrieved 2022/01/19.
• 6、 Guzmán, Jefferson,Bernal, Ana M.,García-Ordu?a, Pilar,Lahoz, Fernando J.,Oro, Luis A.,Fernández-Alvarez, Francisco J.. "Selective reduction of formamides to O-silylated hemiaminals or methylamines with HSiMe2Ph catalyzed by iridium complexes". . p. 4255 - 4262. Retrieved 2019/04/01.