8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol

Base Information

• Chemical Name: 8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol
• CAS No.: 155366-01-1
• Molecular Formula: C14H16 F2 O3
• Molecular Weight: 270.276
• Mol file: 155366-01-1.mol

Synonyms:8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol

Chemical Property of 8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol

Chemical Property:

• PSA: 38.69000
• LogP: 2.46950

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol

There total 1 articles about 8-(3,5-difluorophenyl)-1,4-dioxaspiro(4,5)decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

cyclohexanedione monoethylene ketal (4746-97-8) + 3,5-difluorobromobenzene (461-96-1) → 4-(3,5-difluorophenyl)-4-hydroxycyclohexanone ethylene ketal (155366-01-1)

Guidance literature:

3,5-difluorobromobenzene; With magnesium; In tetrahydrofuran;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; toluene; at 60 ℃; for 3h;

Reference yield:

4-(3,5-difluorophenyl)-4-hydroxycyclohexanone ethylene ketal (155366-01-1) → 1-(3,5-difluorophenyl)-4-cyclohexenone ethylene ketal (155366-02-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In ethylene glycol; xylene; Heating;

DOI:10.1080/10587250108025063

Reference yield:

4-(3,5-difluorophenyl)-4-hydroxycyclohexanone ethylene ketal (155366-01-1) → 4-(3,5-difluorophenyl)cyclohexan-1-one (156265-95-1)

Guidance literature:

Multi-step reaction with 3 steps

1: PTS / xylene; ethane-1,2-diol / Heating

2: H₂ / Pd/C / tetrahydrofuran

3: formic acid / toluene

With formic acid; hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal; In tetrahydrofuran; ethylene glycol; toluene; xylene;

DOI:10.1080/10587250108025063

upstream raw materials:

cyclohexanedione monoethylene ketal

3,5-difluorobromobenzene

Downstream raw materials:

1-(3,5-difluorophenyl)-4-cyclohexenone ethylene ketal

4-(3,5-difluorophenyl)cyclohexan-1-one

Refernces

• 1、 -. "Method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers". Paragraph 0042-0044. . Retrieved 2018/03/01.
• 2、 -. "Fluorinated compounds containing naphthalene structure". Paragraph 0140. . Retrieved 2016/11/17.