5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL

Base Information

• Chemical Name: 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL
• CAS No.: 867012-70-2
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• Mol file: 867012-70-2.mol

Synonyms:3-Amino-6-methoxy-5-methylpyridine;6-Methoxy-5-methyl-3-pyridinamine;

Chemical Property of 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL

Chemical Property:

• Vapor Pressure: 0.00808mmHg at 25°C
• Melting Point: 53-57°C
• Refractive Index: 1.553
• Boiling Point: 267.6 °C at 760 mmHg
• PKA: 4.62±0.20(Predicted)
• Flash Point: 115.6 °C
• PSA: 48.14000
• Density: 1.103g/cm³
• LogP: 1.56200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

3-Amino-6-methoxy-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL

There total 4 articles about 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methoxy-3-methyl-5-nitropyridine (89694-10-0) → 6-methoxy-5-methylpyridin-3-amine (867012-70-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 18 - 25 ℃; for 1h;

Reference yield:

2-methoxy-3-methylpyridine (19230-59-2) → 6-methoxy-5-methylpyridin-3-amine (867012-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2.17 h

With sulfuric acid; hydrogen; nitric acid; palladium 10% on activated carbon; In methanol;

Reference yield:

2-fluoro-3-methylpyridine (2369-18-8) → 6-methoxy-5-methylpyridin-3-amine (867012-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.25 h / Heating / reflux

2: sulfuric acid; nitric acid / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2.17 h

With sulfuric acid; hydrogen; nitric acid; palladium 10% on activated carbon; In methanol;

upstream raw materials:

2-methoxy-3-methyl-5-nitropyridine

2-chloro-3-methyl-5-nitropyridine

2-methoxy-3-methylpyridine

2-fluoro-3-methylpyridine

Refernces

• 1、 Fernandez, Maria-Carmen,Escribano, Ana,Mateo, Ana I.,Parthasarathy, Saravanan,Martin De La Nava, Eva M.,Wang, Xiaodong,Cockerham, Sandra L.,Beyer, Thomas P.,Schmidt, Robert J.,Cao, Guoqing,Zhang, Youyan,Jones, Timothy M.,Borel, Anthony,Sweetana, Stephanie A.,Cannady, Ellen A.,Stephenson, Gregory,Frank, Scott,Mantlo, Nathan B.. "Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors". supporting information; scheme or table. p. 3056 - 3062. Retrieved 2012/06/17.