(1-Methyl-piperidin-4-yl)-acetaldehyde

Base Information

• Chemical Name: (1-Methyl-piperidin-4-yl)-acetaldehyde
• CAS No.: 10333-64-9
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Hs Code.: 2933399090
• Mol file: 10333-64-9.mol

Synonyms:1-Methyl-4-piperidineacetaldehyde;

Chemical Property of (1-Methyl-piperidin-4-yl)-acetaldehyde

Chemical Property:

• Vapor Pressure: 0.296mmHg at 25°C
• Refractive Index: 1.449
• Boiling Point: 202.179 °C at 760 mmHg
• PKA: 9.19±0.10(Predicted)
• Flash Point: 64.192 °C
• PSA: 20.31000
• Density: 0.927 g/cm³
• LogP: 0.85510
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-4-piperidineacetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-4-piperidineacetaldehyde is used as in the preparation of potent and selective agonists for 5-HTID, used as antipsychotics.

Technology Process of (1-Methyl-piperidin-4-yl)-acetaldehyde

There total 6 articles about (1-Methyl-piperidin-4-yl)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-methyl-piperidine-4-carboxaldehyde (50675-21-3) → 1-methyl-4 (formylmethyl)piperidine (10333-64-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h;

N-methyl-piperidine-4-carboxaldehyde; In tetrahydrofuran; at 0 - 25 ℃; for 16h;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield: 69.0%

→ 1-methyl-4 (formylmethyl)piperidine (10333-64-9)

Guidance literature:

Reference yield:

4-(2,2-dimethoxyethyl)-1-methylpiperidine (10333-62-7) → 1-methyl-4 (formylmethyl)piperidine (10333-64-9)

Guidance literature:

With hydrogenchloride; In water;

upstream raw materials:

N-Methyl-4-(carbomethoxymethylidenyl)piperidine

1-Methyl-4-piperidone

(1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester

4-(2,2-dimethoxyethyl)-1-methylpiperidine

Downstream raw materials:

naratriptan

Refernces

• 1、 Sternfeld, Francine,Baker, Raymond,Broughton, Howard B.,Guiblin, Alexander R.,Jelley, Richard A.,Matassa, Victor G.,Reeve, Austin J.,Beer, Margaret S.,Stanton, Josephine A.,Hargreaves, Richard J.,Shepheard, Sara L.,Longmore, Jeanette,Razzaque, Zerin,Graham, Michael I.,Sohal, Bindi,Street, Leslie J.. "The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT(1D) receptors". . p. 1825 - 1830. Retrieved 2007/10/03.
• 2、 -. "4-Substituted 1,2,4-triazole derivatives". . . Retrieved 2008/06/13.