OTAVA-BB 7020690004

Base Information

• Chemical Name: OTAVA-BB 7020690004
• CAS No.: 90032-83-0
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.21
• Hs Code.: 2934999090
• Mol file: 90032-83-0.mol

Synonyms:OTAVA-BB 7020690004;2-morpholinone, 3,3,5,5-tetramethyl-;

Chemical Property of OTAVA-BB 7020690004

Chemical Property:

• PSA: 38.33000
• Density: 0.942
• LogP: 1.01880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

3,3,5,5-Tetramethylmorpholin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of OTAVA-BB 7020690004

There total 3 articles about OTAVA-BB 7020690004 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-Amino-2-methyl-1-propanol (124-68-5) + acetone (67-64-1) → 3,3,5,5-tetramethyl-2-oxomorpholine (90032-83-0)

Guidance literature:

2-Amino-2-methyl-1-propanol; acetone; With sodium hydroxide; In chloroform; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; for 6h; Reflux;

DOI:10.1002/anie.201508912

Reference yield: 54.0%

chloroform (67-66-3,8013-54-5) + 2-Amino-2-methyl-1-propanol (124-68-5) + acetone (67-64-1) → 3,3,5,5-tetramethyl-2-oxomorpholine (90032-83-0)

Guidance literature:

chloroform; 2-Amino-2-methyl-1-propanol; acetone; With sodium hydroxide; at 5 - 20 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In water; for 6h; Reflux;

DOI:10.1021/jacs.5b05529

Reference yield:

sodium 2-[2-methyl-1-hydroxy-2-propylamino]-2-methylpropionate (91377-78-5) → 3,3,5,5-tetramethyl-2-oxomorpholine (90032-83-0)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction; 1.) reflux, 15 h, 2.) reflux, 6 h;

DOI:10.1055/s-1984-30746

upstream raw materials:

sodium 2-[2-methyl-1-hydroxy-2-propylamino]-2-methylpropionate

chloroform

2-Amino-2-methyl-1-propanol

acetone

Downstream raw materials:

N,N-bis(2-methyl-3-hydroxypropyl-2)amine

3,3,5,5-tetramethylmorpholine

Refernces

• 1、 Smalley, Adam P.,Gaunt, Matthew J.. "Mechanistic Insights into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C-H Activation". . p. 10632 - 10641. Retrieved 2015.
• 2、 He, Chuan,Gaunt, Matthew J.. "Ligand-Enabled Catalytic C-H Arylation of Aliphatic Amines by a Four-Membered-Ring Cyclopalladation Pathway". supporting information. p. 15840 - 15844. Retrieved 2016/01/29.