3-Methoxy-5-nitrobenzotrifluoride

Base Information

• Chemical Name: 3-Methoxy-5-nitrobenzotrifluoride
• CAS No.: 328-79-0
• Molecular Formula: C8H6F3NO3
• Molecular Weight: 221.136
• Hs Code.: 2909309090
• Mol file: 328-79-0.mol

Synonyms:Anisole,3-nitro-5-(trifluoromethyl)- (7CI,8CI);1-Methoxy-3-nitro-5-trifluoromethylbenzene;3-Methoxy-5-(trifluoromethyl)-1-nitrobenzene;3-Methoxy-5-nitrobenzotrifluoride;3-Nitro-5-(trifluoromethyl)phenyl methylether;

Chemical Property of 3-Methoxy-5-nitrobenzotrifluoride

Chemical Property:

• Melting Point: 36-38 °C(lit.)
• Boiling Point: 246.9 °C at 760 mmHg
• Flash Point: 103.1 °C
• PSA: 55.05000
• Density: 1.392g/cm³
• LogP: 3.14540
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3-Methoxy-5-nitrobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): CXi
• Hazard Codes: C,Xi
• Statements: 34-36/38-21/22
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxy-5-nitrobenzotrifluoride may be used in chemical synthesis.

Technology Process of 3-Methoxy-5-nitrobenzotrifluoride

There total 5 articles about 3-Methoxy-5-nitrobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dinitrobenzotrifluoride (401-99-0) + sodium methylate (124-41-4) → 1-methoxy-3-nitro-5-trifluoromethyl-benzene (328-79-0)

Guidance literature:

With methanol;

DOI:10.1021/ja01613a076

Reference yield:

methanol (67-56-1) + 3,5-dinitrobenzotrifluoride (401-99-0) → 1-methoxy-3-nitro-5-trifluoromethyl-benzene (328-79-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (479411-93-3) → 1-methoxy-3-nitro-5-trifluoromethyl-benzene (328-79-0)

Guidance literature:

With copper diacetate; triethylamine; sodium nitrite; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1002/chem.201901633

upstream raw materials:

3,5-dinitrobenzotrifluoride

sodium methylate

3-nitro-5-(trifluoromethyl)phenol

dimethyl sulfate

Downstream raw materials:

3-hydroxy-5-(trifluoromethyl)benzonitrile

3-methoxy-5-(trifluoromethyl)benzonitrile

1-iodo-3-methoxy-5-(trifluoromethyl)benzene

N,N-dimethyl-2-(3-nitro-5-(trifluoromethyl)phenoxy)ethanamine

Refernces

• 1、 -. "2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS". Paragraph 0367. . Retrieved 2014/07/08.