(2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE

Base Information

• Chemical Name: (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE
• CAS No.: 10449-07-7
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2928000090
• Mol file: 10449-07-7.mol

Synonyms:Hydrazine,(o-chlorophenyl)- (7CI,8CI);(2-Chlorophenyl)hydrazine;(o-Chlorophenyl)hydrazine;1-(2-Chlorophenyl)hydrazine;NSC 129711;

Chemical Property of (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0197mmHg at 25°C
• Melting Point: 47 °C
• Refractive Index: 1.655
• Boiling Point: 252.1 °C at 760 mmHg
• PKA: 4.60±0.10(Predicted)
• Flash Point: 106.2 °C
• PSA: 38.05000
• Density: 1.32 g/cm³
• LogP: 2.39890

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Chlorophenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-chlorophenyl)hydrazine is a useful research reagent used in the preparation of halogen-substituted phenylhydrazine derivatives with antifungal properties.

Technology Process of (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE

There total 10 articles about (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-chloroaniline (95-51-2) + ascorbic acid (50-81-7,98966-42-8) → 2-chlorophenylhydrazido oxalic acid + (2-chlorophenyl)hydrazine (10449-07-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; In dichloromethane; water;

Reference yield: 79.0%

2-chlorobenzenediazonium tetrafluoroborate (1956-97-4) → (2-chlorophenyl)hydrazine (10449-07-7)

Guidance literature:

With borohydride exchange resin; In methanol; at 0 ℃;

DOI:10.1080/00397919708003336

Reference yield: 53.0%

o-chloroaniline (95-51-2) → (2-chlorophenyl)hydrazine (10449-07-7)

Guidance literature:

o-chloroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.25h;

With tin(ll) chloride; In water; at 0 ℃; for 4h;

DOI:10.3762/bjoc.15.74

upstream raw materials:

2-chlorobenzenediazonium

o-chloroaniline

1,3-diphenyl-2,3-diazaprop-2-en-1-one

2-chlorobenzenediazonium chloride

Downstream raw materials:

N-(2-chloro-phenyl)-N-(4-nitro-benzyl)-hydrazine

N-(2-chloro-phenyl)-N-(2-nitro-benzyl)-hydrazine

N-(2-chloro-benzyl)-N-(2-chloro-phenyl)-hydrazine

Refernces

• 1、 Rustler, Karin,Maleeva, Galyna,Bregestovski, Piotr,K?nig, Burkhard. "Azologization of serotonin 5-HT3 receptor antagonists". . p. 780 - 788. Retrieved 2019/04/17.
• 2、 Wang, Xing,Chen, Yong-Fei,Yan, Wei,Cao, Ling-Ling,Ye, Yong-Hao. "Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi". . . Retrieved 2016/12/03.