5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 222970-61-8
• Molecular Formula: C₇H₆N₂O₅
• Molecular Weight: 198.135
• Hs Code.: 2933399090
• Mol file: 222970-61-8.mol

Synonyms:5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;3-Pyridinecarboxylicacid,1,6-dihydro-5-nitro-6-oxo-,methylester(9CI)

Chemical Property of 5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 1.57E-05mmHg at 25°C
• Boiling Point: 365.4°Cat760mmHg
• Flash Point: 174.8°C
• PSA: 104.98000
• Density: 1.49g/cm³
• LogP: 0.59290
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Methyl5-Nitro-6-oxo-1,6-dihydropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER

There total 4 articles about 5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 6-hydroxy-5-nitronicotinic acid (6635-31-0) → 5-carbomethoxy-3-nitro-1H-pyridin-2-one (222970-61-8)

Guidance literature:

With sulfuric acid; at 65 ℃;

Reference yield:

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) → 5-carbomethoxy-3-nitro-1H-pyridin-2-one (222970-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / red fuming HNO₃ / 70 - 80 °C

2: pyridine, SOCl₂ / acetonitrile / 2 h / Heating

3: Et₃N / acetonitrile / 2 h / Ambient temperature

With pyridine; thionyl chloride; nitric acid; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4039(98)02628-8

Reference yield:

6-hydroxy-5-nitronicotinic acid (6635-31-0) → 5-carbomethoxy-3-nitro-1H-pyridin-2-one (222970-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, SOCl₂ / acetonitrile / 2 h / Heating

2: Et₃N / acetonitrile / 2 h / Ambient temperature

With pyridine; thionyl chloride; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4039(98)02628-8

upstream raw materials:

methanol

6-hydroxy-5-nitronicotinic acid

6-hydroxy-3-pyridinecarboxylic acid

Downstream raw materials:

1-methyl-5-nitro-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

3-amino-5-carbomethoxy-1H-pyridin-2-one

Refernces

• 1、 -. "INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE". Paragraph 00373. . Retrieved 2016/09/22.