5-BROMO-2-PHENOXYPYRIMIDINE

Base Information

• Chemical Name: 5-BROMO-2-PHENOXYPYRIMIDINE
• CAS No.: 257280-25-4
• Molecular Formula: C10H7BrN2O
• Molecular Weight: 251.082
• Hs Code.: 2933599090
• Mol file: 257280-25-4.mol

Synonyms:5-Bromo-2-phenoxypyrimidine;

Chemical Property of 5-BROMO-2-PHENOXYPYRIMIDINE

Chemical Property:

• Vapor Pressure: 3.02E-05mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 366.7 °C at 760 mmHg
• Flash Point: 175.6 °C
• PSA: 35.01000
• Density: 1.543 g/cm³
• LogP: 3.03140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-phenoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-PHENOXYPYRIMIDINE

There total 6 articles about 5-BROMO-2-PHENOXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2-iodopyrimidine (183438-24-6) + phenol (108-95-2,27073-41-2) → 5-bromo-2-phenoxypyrimidine (257280-25-4)

Guidance literature:

With potassium carbonate; at 165 ℃; for 4h; Inert atmosphere;

Reference yield: 70.0%

3-(5-bromo-pyrimidin-2-yloxy)-3H-[1,2,3]triazolo[4,5-b]pyridine + phenylboronic acid (98-80-6) → 5-bromo-2-phenoxypyrimidine (257280-25-4)

Guidance literature:

With oxygen; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 10h; Product distribution / selectivity;

Reference yield:

5-Bromo-2-chloropyrimidine (32779-36-5) + phenol (108-95-2,27073-41-2) → 5-bromo-2-phenoxypyrimidine (257280-25-4)

Guidance literature:

With potassium hydroxide; In n-heptane; ethyl acetate; toluene;

upstream raw materials:

5-bromopyrimidin-2-ol

Diphenyliodonium triflate

5-Bromo-2-chloropyrimidine

phenol

Downstream raw materials:

5-(trimethylstannyl)-2-phenoxypyrimidine

2-phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Refernces

• 1、 -. "Method of preparing Quinoline-5,8-dione derivatives for TGase 2 inhibitor". Paragraph 0377-0380. . Retrieved 2020/04/28.
• 2、 -. "Quinoline-5,8-dione derivatives for TGase 2 inhibitor, and the pharmaceutical composition comprising the same". Paragraph 0263-0266. . Retrieved 2019/10/29.