Technology Process of 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxoethyl)-1-naphthamide
There total 11 articles about 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxoethyl)-1-naphthamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
ethyl acetate;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 3 h / Reflux
2.1: ozone / methanol; dichloromethane / -78 °C
3.1: hydroxylamine hydrochloride / ethanol; water / 18 h / 45 °C
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.17 h / 20 °C
5.1: potassium hydrogencarbonate / ethyl acetate / 18 h / 20 °C
6.1: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
7.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C
7.2: 2 h / 20 °C
8.1: Dess-Martin periodane / ethyl acetate / 2 h / 20 °C
With
N-chloro-succinimide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium hydrogencarbonate; Dess-Martin periodane; ozone; triethylamine; HATU; lithium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sulfuric acid / 18 h / Reflux
2.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 3 h / Reflux
3.1: ozone / methanol; dichloromethane / -78 °C
4.1: hydroxylamine hydrochloride / ethanol; water / 18 h / 45 °C
5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.17 h / 20 °C
6.1: potassium hydrogencarbonate / ethyl acetate / 18 h / 20 °C
7.1: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
8.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C
8.2: 2 h / 20 °C
9.1: Dess-Martin periodane / ethyl acetate / 2 h / 20 °C
With
N-chloro-succinimide; sulfuric acid; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium hydrogencarbonate; Dess-Martin periodane; ozone; triethylamine; HATU; lithium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;