4-CHLORO-2-METHYLPYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-2-METHYLPYRIMIDINE
• CAS No.: 4994-86-9
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.561
• Hs Code.: 2933599090
• Mol file: 4994-86-9.mol

Synonyms:NSC 165514;

Chemical Property of 4-CHLORO-2-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 2.055mmHg at 25°C
• Melting Point: 55.0 to 59.0 °C
• Refractive Index: 1.53
• Boiling Point: 169.319 °C at 760 mmHg
• PKA: 0.47±0.20(Predicted)
• Flash Point: 70.061 °C
• PSA: 25.78000
• Density: 1.235 g/cm³
• LogP: 1.43840
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-2-methylpyrimidine is a reagent in the preparation of (pyridylmethyl)-/(pyrimidin-4-ylmethyl)-dihydroquinolines as antagonists against CXCR4.

Technology Process of 4-CHLORO-2-METHYLPYRIMIDINE

There total 12 articles about 4-CHLORO-2-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.55%

4-hydroxy-2-methyl-pyrimidine (19875-04-8) → 4-chloro-2-methylpyrimidine (4994-86-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 10 - 45 ℃; for 5h; Reagent/catalyst; Temperature;

Reference yield:

2-methyl-3H-pyrimidin-4-one (19875-04-8,127892-80-2) → 4-chloro-2-methylpyrimidine (4994-86-9)

Guidance literature:

2-methyl-3H-pyrimidin-4-one; With trichlorophosphate; at 80 ℃; for 1.5h;

With sodium hydroxide; In water; at 0 ℃;

Reference yield:

2-methylpyrimidin-4-one (19875-04-8) → 4-chloro-2-methylpyrimidine (4994-86-9)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

2-methylimidazole

chloroform

2,4-dimethyl-2-imidazoline

2-methyl-3H-pyrimidin-4-one

Downstream raw materials:

sulphamerazine

2-methylpyrimidine

2-methyl-pyrimidin-4-ylamine

1-(2-methylpyrimidin-4-yl)piperazine

Refernces

• 1、 -. "ANTIVIRAL AGENT". Page 168. . Retrieved 2010/02/06.
• 2、 -. "SUBSTITUTED THIENOIMIDAZOLE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE THEREOF AS INHIBITORS OF GASTRIC ACID SECRETION, AS GASTROPROTECTIVES AND AS MEDICAMENTS FOR INTESTINAL INFLAMMATIONS". . . Retrieved 2008/06/13.