1-(4-Nitrobenzyl)-1H-imidazole

Base Information

• Chemical Name: 1-(4-Nitrobenzyl)-1H-imidazole
• CAS No.: 18994-90-6
• Molecular Formula: C10H9N3O2
• Molecular Weight: 203.2
• Hs Code.: 2933290090
• Mol file: 18994-90-6.mol

Synonyms:Imidazole,1-(p-nitrobenzyl)- (8CI);1-(4-Nitrobenzyl)-1H-imidazole;1-(4-Nitrobenzyl)imidazole;4-(1-Imidazolylmethyl)-1-nitrobenzene;4-(1-Imidazolylmethyl)nitrobenzene;

Chemical Property of 1-(4-Nitrobenzyl)-1H-imidazole

Chemical Property:

• Boiling Point: 418.5 °C at 760 mmHg
• Flash Point: 206.9 °C
• PSA: 63.64000
• Density: 1.29 g/cm³
• LogP: 2.36280

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Nitrobenzyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Nitrobenzyl)-1H-imidazole

There total 10 articles about 1-(4-Nitrobenzyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1H-imidazole (288-32-4) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 1-(4-nitrobenzyl)-1H-imidazole (18994-90-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 12h;

DOI:10.3390/pharmaceutics13030312

Reference yield: 95.0%

1H-imidazole (288-32-4) + 4-nitrobenzyl chloride (100-14-1) → 1-(4-nitrobenzyl)-1H-imidazole (18994-90-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 15h; Irradiation;

DOI:10.1016/S0040-4039(00)85434-9

Reference yield: 94.0%

4-nitrobenzyl chloride (619-73-8) + 1,1'-carbonyldiimidazole (530-62-1) → 1-(4-nitrobenzyl)-1H-imidazole (18994-90-6)

Guidance literature:

In diethylene glycol dimethyl ether; at 170 ℃; for 18h;

DOI:10.1055/s-2004-831215

upstream raw materials:

1H-imidazole

4-nitrobenzyl chloride

1-bromomethyl-4-nitro-benzene

4-nitrobenzyl chloride

Downstream raw materials:

N-(4-Imidazol-1-ylmethyl-phenyl)-phthalamic acid

(4-Imidazol-1-ylmethyl-phenyl)-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine

N-(4-{[(E)-4-Imidazol-1-ylmethyl-phenylimino]-methyl}-phenyl)-acetamide

(4-Imidazol-1-ylmethyl-phenyl)-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amine

Refernces

• 1、 Khalili Arjomandi, Omid,Kavoosi, Mahboubeh,Adibi, Hadi. "Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1". . . Retrieved 2019/09/19.
• 2、 Song, Zhendong,Jin, Yue,Ge, Yang,Wang, Changyuan,Zhang, Jianbin,Tang, Zeyao,Peng, Jinyong,Liu, Kexin,Li, Yanxia,Ma, Xiaodong. "Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors". . p. 5505 - 5512. Retrieved 2016/10/24.