5-P-TOLYLPYRIDIN-2-YLAMINE

Base Information

• Chemical Name: 5-P-TOLYLPYRIDIN-2-YLAMINE
• CAS No.: 503536-74-1
• Molecular Formula: C12H12 N2
• Molecular Weight: 184.24
• Hs Code.: 2933399090
• Mol file: 503536-74-1.mol

Synonyms:5-(4-METHYLPHENYL)-2-PYRIDINAMINE;AKOS BAR-0885;5-P-TOLYLPYRIDIN-2-YLAMINE;5-P-TOLYLPYRIDIN-2-YLAMINE, 95+%

Chemical Property of 5-P-TOLYLPYRIDIN-2-YLAMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 334.363oC at 760 mmHg
• Flash Point: 182.486oC
• PSA: 38.91000
• Density: 1.107g/cm3
• LogP: 3.22040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Methylphenyl)pyridin-2-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-P-TOLYLPYRIDIN-2-YLAMINE

There total 2 articles about 5-P-TOLYLPYRIDIN-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-2-pyridylamine (1072-97-5) + 4-methylphenylboronic acid (5720-05-8) → 5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h;

DOI:10.1016/j.bmcl.2017.07.072

Reference yield: 63.0%

N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide (910791-86-5) → 5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1) + 3-(4''-methylphenyl)-dipyrido[1,2-b;3',2'-d]pyrazole (1087037-18-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In acetonitrile; benzene; for 32h;

DOI:10.1021/jo801549u

Reference yield: 74.0%

5-(4-methylphenyl)pyridin-2-ylamine (503536-74-1) + 1-(2-bromophenyl)-4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine] (1554015-91-6) → C36H41ClN4O (1609548-30-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 110 ℃; for 16h;

DOI:10.1016/j.bmcl.2014.04.011

upstream raw materials:

N-[(3'-bromo-5'-(4''-methylphenyl))pyridin-2-yl]pyridinium aminide

5-bromo-2-pyridylamine

4-methylphenylboronic acid

Downstream raw materials:

N-[5-(4-methylphenyl)pyridin-2-yl]benzamide

C₃₆H₄₁ClN₄O

3-bromo-5-(4-methylphenyl)-2-pyridinamine

Refernces

• 1、 Abet, Valentina,Nunez, Araceli,Mendicuti, Francisco,Burgos, Carolina,Alvarez-Builla, Julio. "A new class of pyrazolopyridine nucleus with fluorescent properties, obtained through either a radical or a Pd arylation pathway from N-azinylpyridinium N-aminides". scheme or table. p. 8800 - 8807. Retrieved 2009/04/11.