3-FLUORO-2-IODOBENZOIC ACID

Base Information

• Chemical Name: 3-FLUORO-2-IODOBENZOIC ACID
• CAS No.: 387-48-4
• Molecular Formula: C7H4FIO2
• Molecular Weight: 266.01
• Hs Code.: 2916399090
• Mol file: 387-48-4.mol

Synonyms:BUTTPARK 122\01-05;3-FLUORO-2-IODOBENZOIC ACID;2-IODO-3-FLUOROBENZOIC ACID;3-Fluoro-2-Iodobenzoic Acid 2-Iodo-3-Fluorobenzoic Acid;3-Fluoro-2-iodobenzoic;3-FLUORO-2-IODOBENZOIC ACID,98%

Chemical Property of 3-FLUORO-2-IODOBENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 152-153 °C
• Refractive Index: 1.638
• Boiling Point: 313.97 °C at 760 mmHg
• PKA: 2.52±0.10(Predicted)
• Flash Point: 143.684 °C
• PSA: 37.30000
• Density: 2.074 g/cm³
• LogP: 2.12850
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-2-iodobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-FLUORO-2-IODOBENZOIC ACID

There total 4 articles about 3-FLUORO-2-IODOBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-fluorobenzoic acid (455-38-9) → 3-fluoro-2-iodobenzoic acid (387-48-4)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; iodine; silver(I) acetate; triethylamine; at 23 ℃; for 18h; regioselective reaction; Sealed tube;

DOI:10.1002/chem.202002204

Reference yield: 19.0%

3-fluoroanthranilic acid (825-22-9) → 3-fluoro-2-iodobenzoic acid (387-48-4)

Guidance literature:

Reference yield:

3-amino-2-iodo-benzoic acid (85600-30-2) → 3-fluoro-2-iodobenzoic acid (387-48-4)

Guidance literature:

With hydrogen fluoride; Behandeln der erhaltenen Suspension mit Natriumnitrit;

DOI:10.1021/ja01329a039

upstream raw materials:

3-amino-2-iodo-benzoic acid

2-iodo-3-nitrobenzoic acid

3-fluoroanthranilic acid

3-fluorobenzoic acid

Downstream raw materials:

3-fluoro-2-(1H-pyrazol-1-yl)benzoic acid

ethyl 3-fluoro-2-iodobenzoate

ethyl 2-(3-fluoro-2-(3,3,3-triethoxyprop-1-ynyl)phenyl)acetate

ethyl 2-(3-fluoro-2-iodophenyl)acetate

Refernces

• 1、 Erbing, Elis,Sanz-Marco, Amparo,Vázquez-Romero, Ana,Malmberg, Jesper,Johansson, Magnus J.,Gómez-Bengoa, Enrique,Martín-Matute, Belén. "Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations". . p. 920 - 925. Retrieved 2018/02/14.
• 2、 -. "Condensed pyrazole derivatives, process for producing the same and use thereof". . . Retrieved 2008/06/13.