S-(p-tolyl) furan-2-carbothioate

Base Information

• Chemical Name: S-(p-tolyl) furan-2-carbothioate
• CAS No.: 17357-39-0
• Molecular Formula: C₁₂H₁₀O₂S
• Molecular Weight: 218.276
• Mol file: 17357-39-0.mol

Synonyms:S-(p-tolyl) furan-2-carbothioate

Chemical Property of S-(p-tolyl) furan-2-carbothioate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of S-(p-tolyl) furan-2-carbothioate

There total 9 articles about S-(p-tolyl) furan-2-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-furancarbonyl chloride (527-69-5) + sodium 4-methylbenzenesulfinate (824-79-3) → S-(p-tolyl) furan-2-carbothioate (17357-39-0)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 23 ℃; for 6h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.9b01218

Reference yield: 80.0%

N,N-Boc2-furan-2-carboxamide + para-thiocresol (106-45-6) → S-(p-tolyl) furan-2-carbothioate (17357-39-0)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1177/1747519819873514

Reference yield: 67.0%

di(p-tolyl) disulfide (103-19-5) + 2-furoyl-1H-1,2,3-benzotriazole (144223-33-6) → S-(p-tolyl) furan-2-carbothioate (17357-39-0)

Guidance literature:

With rongalite; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

DOI:10.1590/S0103-50532010000900003

upstream raw materials:

2-furancarbonyl chloride

para-thiocresol

di(p-tolyl) disulfide

2-furoyl-1H-1,2,3-benzotriazole

Downstream raw materials:

p-methylphenyl dithio-2-furoate

C₂₀H₂₄O₂S

C₂₀H₂₄O₂S

Refernces

• 1、 Qi, Xinxin,Bao, Zhi-Peng,Yao, Xin-Tong,Wu, Xiao-Feng. "Nickel-Catalyzed Thiocarbonylation of Arylboronic Acids with Sulfonyl Chlorides for the Synthesis of Thioesters". supporting information. p. 6671 - 6676. Retrieved 2020/09/02.
• 2、 Xuan, Maojie,Lu, Chunlei,Liu, Meina,Lin, Bo-Lin. "Air-Tolerant Direct Thiol Esterification with Carboxylic Acids Using Hydrosilane via Simple Inorganic Base Catalysis". . p. 7694 - 7701. Retrieved 2019/06/27.