1-Trimethylsilyl-1-hexyne

Base Information

• Chemical Name: 1-Trimethylsilyl-1-hexyne
• CAS No.: 3844-94-8
• Molecular Formula: C9H18Si
• Molecular Weight: 154.327
• Hs Code.: 2931900090
• Mol file: 3844-94-8.mol

Synonyms:Silane,1-hexynyltrimethyl- (6CI,7CI,8CI,9CI);1-(Trimethylsilyl)-2-butylacetylene;1-Butyl-2-trimethylsilylacetylene;1-Hexynyltrimethylsilane;Butyl(trimethylsilyl)acetylene;

Chemical Property of 1-Trimethylsilyl-1-hexyne

Chemical Property:

• Vapor Pressure: 4.25mmHg at 25°C
• Refractive Index: n20/D 1.431(lit.)
• Boiling Point: 153.6 °C at 760 mmHg
• Flash Point: 37.2 °C
• PSA: 0.00000
• Density: 0.787 g/cm³
• LogP: 3.05740

Purity/Quality:

99% ^*data from raw suppliers

1-Trimethylsilyl-1-hexyne ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Trimethylsilyl-1-hexyne

There total 18 articles about 1-Trimethylsilyl-1-hexyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloro-trimethyl-silane (75-77-4) + hex-1-yne (693-02-7) → 1-(trimethylsilyl)-1-hexyne (3844-94-8)

Guidance literature:

hex-1-yne; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 1.33333h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3nj00334e

Reference yield: 80.0%

trimethylsilyl iodide (16029-98-4) + hex-1-yne (693-02-7) → 1-(trimethylsilyl)-1-hexyne (3844-94-8)

Guidance literature:

With magnesium; Heating;

DOI:10.1007/BF00949741

Reference yield: 80.0%

trimethylsilyl cyanide (7677-24-9) + 1-hexynyllithium (17689-03-1) → 1-(trimethylsilyl)-1-hexyne (3844-94-8)

Guidance literature:

In tetrahydrofuran; at -20 ℃;

DOI:10.1021/jo00368a030

upstream raw materials:

hexenylmagnesium bromide

chloro-trimethyl-silane

hex-1-yne

tripropylborane

Downstream raw materials:

(Z)-hex-1-enyl(trimethyl)silane

(E)-1-trimethylsilyl-1-hexene

Tetramethyl ethylenetetracarboxylate

dimethyl ester of 1-butyl-2-(trimethylsilyl)cyclopropene-3,3-dicarboxylic acid

Refernces

• 1、 Nicholson, Joshua M.,Millham, Adam B.,Bucknam, Andrea R.,Markham, Lauren E.,Sailors, Xenia Ivanna,Micalizio, Glenn C.. "General Enantioselective and Stereochemically Divergent Four-Stage Approach to Fused Tetracyclic Terpenoid Systems". supporting information. p. 3352 - 3362. Retrieved 2022/03/02.
• 2、 Chiu, Hsin-Chun,Tonks, Ian A.. "Trimethylsilyl-Protected Alkynes as Selective Cross-Coupling Partners in Titanium-Catalyzed [2+2+1] Pyrrole Synthesis". supporting information. p. 6090 - 6094. Retrieved 2018/05/30.