S-2-Aminononanoic acid

Base Information

• Chemical Name: S-2-Aminononanoic acid
• CAS No.: 133444-84-5
• Molecular Formula: C₉H₁₉NO₂
• Molecular Weight: 173.255
• Hs Code.: 2922499990
• Mol file: 133444-84-5.mol

Synonyms:Nonanoicacid, 2-amino-, (S)-

Chemical Property of S-2-Aminononanoic acid

Chemical Property:

• Boiling Point: 284.5±23.0 °C(Predicted)
• PKA: 2.55±0.24(Predicted)
• PSA: 63.32000
• Density: 0.985±0.06 g/cm3(Predicted)
• LogP: 2.45910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(S)-2-Aminononanoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2-Aminononanoic acid

There total 7 articles about S-2-Aminononanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-oxononanoic acid (13139-94-1) → (S)-2-amino-nonanoic acid (133444-84-5)

Guidance literature:

With formate dehydrogenase; NAD; ammonium formate; at 30 ℃; for 24h; PheDH;

DOI:10.1021/jo00308a012

Reference yield: 72.0%

nonanoic acid (112-05-0) → (S)-2-amino-nonanoic acid (133444-84-5)

Guidance literature:

nonanoic acid; With P_450CLA; dihydrogen peroxide; In aq. phosphate buffer; ethanol; at 20 ℃; for 20h; pH=7; Enzymatic reaction;

With D-HIC-DH; L-HIC-DH; L-Phe-DH; NAD; ammonium carbonate; ammonium chloride; In aq. phosphate buffer; ethanol; at 20 ℃; for 24h; pH=8; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/adsc.201801377

Reference yield:

(E)-(S)-2-Dibenzylamino-non-5-enoic acid benzyl ester → (S)-2-amino-nonanoic acid (133444-84-5)

Guidance literature:

With hydrogen; palladium dihydroxide;

DOI:10.1055/s-2004-834865

upstream raw materials:

2-oxononanoic acid

1-Bromoheptane

ethyl 2-oxononaoate

nonanoic acid

Downstream raw materials:

(S)-2-(3-((S)-1-carboxyoctyl)ureido)-6-(4-iodobenzamido)hexanoic acid

Refernces

• 1、 Liu, Yayun,Meng, Lijun,Wu, Jianping,Yang, Lirong,Yin, Xinjian,Zhou, Haisheng. "Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates". . p. 3376 - 3386. Retrieved 2020/06/09.
• 2、 Dennig, Alexander,Blaschke, Fabio,Gandomkar, Somayyeh,Tassano, Erika,Nidetzky, Bernd. "Preparative Asymmetric Synthesis of Canonical and Non-canonical a-amino Acids through Formal Enantioselective Biocatalytic Amination of Carboxylic Acids". . p. 1348 - 1358. Retrieved 2019/10/28.