(3S,2S)-2,3-Diaminobutyric acid 2HCl

Base Information

• Chemical Name: (3S,2S)-2,3-Diaminobutyric acid 2HCl
• CAS No.: 121054-30-6
• Molecular Formula: C₄H₁₀N₂O₂*2ClH
• Molecular Weight: 191.057
• Mol file: 121054-30-6.mol

Synonyms:Butanoic acid,2,3-diamino-, dihydrochloride, (R*,R*)- (9CI); Butanoic acid, 2,3-diamino-,dihydrochloride, (R*,R*)-(?à)-

Chemical Property of (3S,2S)-2,3-Diaminobutyric acid 2HCl

Chemical Property:

• PSA: 89.34000
• LogP: 1.75010

Purity/Quality:

99% ^*data from raw suppliers

(3S,2S)-2,3-Diaminobutyric acid 2HCl 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3S,2S)-2,3-Diaminobutyric Acid Dihydrochloride is used in preparation of HPLC on bonded phase with L-Proline.

Technology Process of (3S,2S)-2,3-Diaminobutyric acid 2HCl

There total 6 articles about (3S,2S)-2,3-Diaminobutyric acid 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,3R)-2-Acetylamino-3-benzyloxycarbonylamino-butyric acid methyl ester (215652-47-4) → (2S,3R)-2,3-diaminobutanoic acid dichloride (121054-30-6,648922-13-8)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 6h;

DOI:10.1016/S0957-4166(98)00297-3

Reference yield: 95.0%

ethyl (2S,3R)-2,3-bis-N-tert-butoxycarbonylamino butanoate (389631-23-6) → (2S,3R)-2,3-diaminobutanoic acid dichloride (121054-30-6,648922-13-8)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1016/S0040-4020(01)00823-7

Reference yield: 92.0%

(4R,5S)-1-benzyl 4-carbomethoxy-3-ethanoyl-5-methyl-2-oxoimidazolidine-1-carboxylate (917839-23-7) → (2R,3S)-2,3-diaminobutanoic acid dihydrochloride (121054-30-6,648922-13-8)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 24h;

DOI:10.1021/ol0621102

upstream raw materials:

(4R,5S)-1-benzyl 4-carbomethoxy-3-ethanoyl-5-methyl-2-oxoimidazolidine-1-carboxylate

(2S,3R)-2-Acetylamino-3-benzyloxycarbonylamino-butyric acid methyl ester

ethyl (2S,3R)-2,3-bis-N-tert-butoxycarbonylamino butanoate

Refernces

• 1、 Ichikawa, Yoshiyasu,Egawa, Haruka,Ito, Takashi,Isobe, Minoru,Nakano, Keiji,Kotsuki, Hiyoshizo. "Stereocontrolled route to vicinal diamines by [3.3] sigmatropic rearrangement of allyl cyanate: Asymmetric synthesis of anti-(2R,3R)- and syn-(2R,3S)-2,3-diaminobutanoic acids". . p. 5737 - 5740. Retrieved 2007/10/03.
• 2、 Kuwano, Ryoichi,Okuda, Satoshi,Ito, Yoshihiko. "Asymmetric hydrogenation of (E)-α, β-bis(N-acylamino)acrylates catalyzed by a rhodium complex with trans-chelating chiral diphosphine ligand". . p. 2773 - 2775. Retrieved 2007/10/03.