S-2--Bromovaleric acid

Base Information

• Chemical Name: S-2--Bromovaleric acid
• CAS No.: 32835-74-8
• Molecular Formula: C₅H₉BrO₂
• Molecular Weight: 181.029
• Hs Code.: 2915900090
• Mol file: 32835-74-8.mol

Synonyms:L-2-Bromovaleric acid;L-a-Bromovaleric acid;(S)-2-Bromovaleric acid;Valeric acid, 2-bromo-, (S)- (8CI);Pentanoicacid, 2-bromo-, (S)-;(2S)-2-Bromopentanoic acid;

Chemical Property of S-2--Bromovaleric acid

Chemical Property:

• Boiling Point: 232.2 °C at 760 mmHg
• Flash Point: 94.2 °C
• PSA: 37.30000
• Density: 1.518 g/cm³
• LogP: 1.63460

Purity/Quality:

99% ^*data from raw suppliers

S-2-BROMOVALERIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2--Bromovaleric acid

There total 6 articles about S-2--Bromovaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Norvaline (6600-40-4,498-18-0) → (S)-α-Brom-valeriansaeure (32835-74-8)

Guidance literature:

With hydrogen bromide; potassium bromide; sodium nitrite;

DOI:10.1016/S0960-894X(00)00403-0

Reference yield:

1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl pentanoate (171734-64-8) → (S)-α-Brom-valeriansaeure (32835-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: n-BuLi, iPr₂NH / tetrahydrofuran; hexane / 6 h / -70 - 20 °C

2: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C

3: 30percent aq. H₂O₂, LiOH / tetrahydrofuran / 0.5 h

With lithium hydroxide; N-Bromosuccinimide; n-butyllithium; dihydrogen peroxide; diisopropylamine; In tetrahydrofuran; hexane;

DOI:10.1016/0957-4166(95)00251-J

Reference yield:

1-<1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyloxy>-1-trimethylsilyloxy-pent-1-ene → (S)-α-Brom-valeriansaeure (32835-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C

2: 30percent aq. H₂O₂, LiOH / tetrahydrofuran / 0.5 h

With lithium hydroxide; N-Bromosuccinimide; dihydrogen peroxide; In tetrahydrofuran;

DOI:10.1016/0957-4166(95)00251-J

upstream raw materials:

L-Norvaline

1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl pentanoate

valeric acid

Refernces

• 1、 Fink, Cynthia A.,Moskal, Michael,Firooznia, Fariborz,Hoyer, Denton,Symonsbergen, David,Wei, Dongchu,Qiao, Ying,Savage, Paula,Beil, Michael E.,Trapani, Angelo J.,Jeng, Arco Y.. "Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1". . p. 2037 - 2039. Retrieved 2007/10/03.