2-Bromopyrrole

Base Information

• Chemical Name: 2-Bromopyrrole
• CAS No.: 38480-28-3
• Molecular Formula: C4H4 Br N
• Molecular Weight: 145.986
• Hs Code.: 2933990090
• Mol file: 38480-28-3.mol

Synonyms:2-Bromopyrrole;2-Pyrrolyl bromide

Chemical Property of 2-Bromopyrrole

Chemical Property:

• Melting Point: 48-50 °C
• Boiling Point: 210.8±13.0 °C(Predicted)
• PKA: 16.02±0.50(Predicted)
• PSA: 15.79000
• Density: 1.739±0.06 g/cm3(Predicted)
• LogP: 1.77720

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-1H-pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-1H-pyrrole can be used as reactant/reagent in preparation and structure-activity relationship of trifluoroalkyl-containing azoles and arenes as inhibitors of β-amyloid self-assembly.

Technology Process of 2-Bromopyrrole

There total 3 articles about 2-Bromopyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyrrole (109-97-7,30604-81-0) → 2-bromo-1H-pyrrole (38480-28-3)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at -15 ℃;

Reference yield:

pyrrole (109-97-7,30604-81-0) → 2,3,4,5-tetrabromopyrrole (54705-14-5) + 2-bromo-1H-pyrrole (38480-28-3) + 2,5-dibromo-1H-pyrrole (56454-25-2) + 2,3,5-tribromopyrrole (77124-07-3)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at -10 ℃; Product distribution; diff. pyrrol/NBS ratio; chlorination with N-chlorosuccinimide was also investigated;

DOI:10.1021/jo00324a005

Reference yield:

→ 2-bromo-1H-pyrrole (38480-28-3)

Guidance literature:

Pyrrolyl-MgBr, Br2;

DOI:10.1021/jo00910a001

upstream raw materials:

pyrrole

Downstream raw materials:

2-(2-nitrophenyl)-1H-pyrrole

2-bromo-1-phenyl-1H-pyrrole

2-pyrrole aldehyde

(4-methoxyphenyl)(1H-pyrrol-2-yl)methanone

Refernces

• 1、 -. "A halogenated nitrogen-containing unsaturated cyclic hydrocarbon preparation method". Paragraph 0016. . Retrieved 2018/05/16.
• 2、 Cho, Dae Won,Fujitsuka, Mamoru,Ryu, Jung Ho,Lee, Myoung Hee,Kim, Hwan Kyu,Majima, Tetsuro,Im, Chan. "S2 emission from chemically modified BODIPYs". supporting information; experimental part. p. 3424 - 3426. Retrieved 2012/05/20.